Figure 8.

The optimal immunogenicity of antibody response to the third dose is achieved over a large time window. The protocols with intervals between the second and third dose between 6 and 16 months achieve peak antibody responses significantly higher (p< 0.05)) than shorter or longer protocols. (A) The plots represent the dynamics of the median (solid lines) and the IQR (shaded area) of variable Ab, in experiments 2A-I. (B) The box plots show the median, IQR, and range of the antibody peak after the third dose, Ab(t_m ).