TABLE 1.
Effect of aminoguanidine on spleen cell composition in Salmonella-immunized mice
| Cell type | Antibody target | % of total cellsa
|
||
|---|---|---|---|---|
| H2O-saline | H2O-SL3235 | AG-SL3235 | ||
| Macrophages and PMNs | Mac-1 (CD11b) | 18 ± 1 | 45 ± 2b | 20 ± 2c |
| T cells | CD3 | 34 ± 1 | 21 ± 2b | 31 ± 2c |
| B cells | sIg | 49 ± 2 | 55 ± 4d | 53 ± 3 |
a
Determined by flow cytometry on day 5 postimmunization. Results are mean ± standard error for six experiments.
b
P ≤ 0.05, H2O-SL3235 versus AG-SL3235 or H2O-saline.
c
Not significant, AG-SL3235 versus H2O-saline.
d
Not significant, H2O-SL3235 versus AG-SL3235 or H2O-saline.