Fig. 1.

Incidence rates of AESI and negative control events in the pre- and peri-COVID-19 periods from six data sources. Abbreviations: AESI, adverse event of special interest; AMI, acute myocardial infarction; BHI, Blue Health Intelligence; CD, colonic diverticulitis; CI, confidence interval; DIC, disseminated intravascular coagulation; DVT, deep vein thrombosis; ENC, encephalitis/encephalomyelitis; GBS, Guillain-Barré syndrome; HS, hemorrhagic stroke; HTN, hypertension; ITP, immune thrombocytopenia; K, thousands; NHS, non-hemorrhagic stroke; PE, pulmonary embolism; TM, transverse myelitis; TTS, thrombosis with thrombocytopenia syndrome; WCV, well-care visit. ^a For MarketScan, the peri-COVID-19 period includes data from March through October 2020; for all other data sources, the peri-COVID-19 period includes data through December 11, 2020. Statistics on negative control events were not available from Optum. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)