Table 2.
Incidence rates for each AESI and negative control eventa by age group (18–64 years) and data source in 2019.
| AESI or negative control and age, years | BHI |
CVS Health |
HealthCore |
MarketScan |
Optuma |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| IR per 100,000 PY (95 % CI) |
IRR (95 % CI) |
IR per 100,000 PY (95 % CI) |
IRR (95 % CI) |
IR per 100,000 PY (95 % CI) |
IRR (95 % CI) |
IR per 100,000 PY (95 % CI) |
IRR (95 % CI) |
IR per 100,000 PY (95 % CI) |
IRR (95 % CI) |
|
| AMI | 149.45 (147.45–151.47) |
110.48 (108.31–112.69) |
122.85 (120.81–124.92) |
110.28 (108.44–112.15) |
134.14 (131.63–136.68) |
|||||
| 18–25 | 5.26 (4.39–6.26) |
[ref] | 3.88 (2.95–5.01) |
[ref] | 4.17 (3.31–5.18) |
[ref] | 4.14 (3.32–5.10) |
[ref] | 6.91 (5.47–8.61) |
[ref] |
| 26–35 | 15.70 (14.13–17.39) |
2.98 (2.43–3.68) |
10.99 (9.44–12.71) |
2.83 (2.10–3.87) |
13.62 (12.03–15.37) |
3.27 (2.54–4.25) |
11.90 (10.45–13.50) |
2.88 (2.25–3.71) |
16.11 (14.18–18.23) |
2.33 (1.80–3.04) |
| 36–45 | 65.13 (62.12–68.25) |
12.37 (10.34–14.92) |
52.05 (48.81–55.44) |
13.41 (10.31–17.76) |
60.35 (57.24–63.58) |
14.48 (11.57–18.34) |
55.58 (52.73–58.54) |
13.44 (10.83–16.86) |
74.06 (70.15–78.14) |
10.72 (8.54–13.63) |
| 46–55 | 195.08 (190.29–199.96) |
37.06 (31.11–44.5) |
152.85 (147.49–158.36) |
39.39 (30.45–51.87) |
171.28 (166.34–176.34) |
41.09 (32.99–51.84) |
148.52 (144.15–152.98) |
35.90 (29.07–44.86) |
192.14 (186.06–198.37) |
27.82 (22.26–35.22) |
| 56–64 | 358.23 (352.04–364.51) |
68.05 (57.18–81.64) |
298.14 (290.33–306.10) |
76.83 (59.47–101.06) |
315.91 (308.81–323.12) |
75.78 (60.89–95.53) |
278.20 (271.94–284.56) |
67.25 (54.51–83.96) |
331.99 (323.23–340.94) |
48.06 (38.50–60.81) |
| Anaphylaxis | 18.67 (18.02–19.33) |
12.46 (11.86–13.09) |
14.81 (14.19–15.45) |
13.90 (13.32–14.49) |
16.66 (15.88–17.47) |
|||||
| 18–25 | 25.96 (24.12–27.90) |
[ref] | 16.07 (14.48–17.79) |
[ref] | 18.33 (16.7–20.07) |
[ref] | 17.72 (16.19–19.37) |
[ref] | 24.11 (21.68–26.73) |
[ref] |
| 26–35 | 18.37 (16.87–19.96) |
0.71 (0.63–0.79) |
11.31 (10.05–12.68) |
0.70 (0.60–0.82) |
12.77 (11.48–14.17) |
0.70 (0.61–0.80) |
13.09 (11.82–14.45) |
0.74 (0.64–0.85) |
15.99 (14.35–17.77) |
0.66 (0.57–0.77) |
| 36–45 | 18.59 (17.12–20.15) |
0.72 (0.64–0.80) |
12.56 (11.23–14.00) |
0.78 (0.67–0.91) |
14.50 (13.16–15.94) |
0.79 (0.69–0.90) |
14.69 (13.40–16.06) |
0.83 (0.73–0.94) |
17.06 (15.40–18.84) |
0.71 (0.61–0.82) |
| 46–55 | 18.11 (16.76–19.53) |
0.70 (0.63–0.78) |
12.87 (11.55–14.28) |
0.80 (0.69–0.93) |
14.81 (13.51–16.21) |
0.81 (0.71–0.92) |
13.42 (12.25–14.68) |
0.76 (0.67–0.86) |
14.88 (13.38–16.51) |
0.62 (0.53–0.72) |
| 56–64 | 14.36 (13.21–15.57) |
0.55 (0.50–0.62) |
9.76 (8.58–11.07) |
0.61 (0.51–0.72) |
13.96 (12.61–15.42) |
0.76 (0.66–0.87) |
11.04 (9.92–12.26) |
0.62 (0.54–0.72) |
13.38 (11.80–15.11) |
0.55 (0.47–0.65) |
| Appendicitis | 152.71 (150.69–154.75) |
117.15 (114.91–119.43) |
128.22 (126.13–130.33) |
118.73 (116.81–120.66) |
155.05 (152.35–157.78) |
|||||
| 18–25 | 201.61 (196.00–207.34) |
[ref] | 148.26 (142.20–154.51) |
[ref] | 167.17 (161.47–173.03) |
[ref] | 154.16 (148.92–159.53) |
[ref] | 223.45 (214.86–232.29) |
[ref] |
| 26–35 | 179.06 (173.67–184.59) |
0.89 (0.85–0.93) |
128.19 (122.77–133.80) |
0.86 (0.81–0.92) |
146.07 (140.73–151.56) |
0.87 (0.83–0.92) |
142.30 (137.17–147.58) |
0.92 (0.88–0.97) |
188.13 (181.37–195.07) |
0.84 (0.80–0.89) |
| 36–45 | 158.59 (153.87–163.42) |
0.79 (0.75–0.82) |
118.75 (113.84–123.82) |
0.80 (0.75–0.85) |
130.01 (125.43–134.71) |
0.78 (0.74–0.82) |
117.36 (113.2–121.64) |
0.76 (0.72–0.80) |
155.10 (149.41–160.96) |
0.69 (0.66–0.73) |
| 46–55 | 136.85 (132.85–140.95) |
0.68 (0.65–0.71) |
108.13 (103.63–112.78) |
0.73 (0.69–0.77) |
110.48 (106.51–114.55) |
0.66 (0.63–0.69) |
104.88 (101.21–108.64) |
0.68 (0.65–0.71) |
129.56 (124.58–134.69) |
0.58 (0.55–0.61) |
| 56–64 | 112.12 (108.67–115.65) |
0.56 (0.53–0.58) |
90.19 (85.93–94.62) |
0.61 (0.57–0.65) |
100.05 (96.08–104.14) |
0.60 (0.57–0.63) |
89.54 (86.02–93.18) |
0.58 (0.55–0.61) |
106.56 (101.62–111.67) |
0.48 (0.45–0.51) |
| Bell’s palsy | 118.58 (116.88–120.31) |
97.84 (95.98–99.72) |
106.89 (105.11–108.7) |
105.47 (103.78–107.19) |
123.67 (121.42–125.96) |
|||||
| 18–25 | 50.21 (47.54–52.98) |
[ref] | 36.65 (33.99–39.47) |
[ref] | 43.52 (40.83–46.35) |
[ref] | 44.29 (41.68–47.01) |
[ref] | 59.49 (55.41–63.79) |
[ref] |
| 26–35 | 88.25 (84.74–91.88) |
1.76 (1.64–1.88) |
68.77 (65.27–72.40) |
1.88 (1.71–2.06) |
78.43 (74.9–82.09) |
1.80 (1.67–1.95) |
79.87 (76.41–83.45) |
1.80 (1.67–1.94) |
97.73 (93.31–102.31) |
1.64 (1.51–1.79) |
| 36–45 | 117.33 (113.45–121.31) |
2.34 (2.19–2.49) |
97.86 (93.79–102.06) |
2.67 (2.45–2.91) |
105.98 (102.10–109.97) |
2.43 (2.26–2.62) |
103.41 (99.75–107.17) |
2.34 (2.18–2.51) |
125.38 (120.58–130.32) |
2.11 (1.95–2.29) |
| 46–55 | 152.05 (147.98–156.21) |
3.03 (2.85–3.22) |
129.76 (125.21–134.42) |
3.54 (3.26–3.85) |
137.83 (133.61–142.14) |
3.17 (2.95–3.40) |
132.42 (128.50–136.42) |
2.99 (2.8–3.20) |
148.96 (143.90–154.16) |
2.5 (2.32–2.71) |
| 56–64 | 157.75 (153.79–161.79) |
3.14 (2.96–3.34) |
144.45 (139.46–149.57) |
3.94 (3.63–4.28) |
153.30 (148.57–158.13) |
3.52 (3.28–3.78) |
149.98 (145.58–154.47) |
3.39 (3.17–3.62) |
165.31 (159.41–171.36) |
2.78 (2.57–3.01) |
| DVT | 285.50 (282.73–288.30) |
232.20 (229.03–235.39) |
238.51 (235.67–241.39) |
242.62 (239.89–245.39) |
226.52 (223.25–229.82) |
|||||
| 18–25 | 57.95 (54.96–61.05) |
[ref] | 39.74 (36.64–43.04) |
[ref] | 44.59 (41.67–47.66) |
[ref] | 46.70 (43.84–49.70) |
[ref] | 54.08 (49.90–58.51) |
[ref] |
| 26–35 | 126.53 (122–131.18) |
2.18 (2.05–2.33) |
89.57 (85.04–94.27) |
2.25 (2.05–2.48) |
97.69 (93.34–102.19) |
2.19 (2.02–2.38) |
103.80 (99.43–108.32) |
2.22 (2.06–2.40) |
105.09 (100.06–110.31) |
1.94 (1.77–2.14) |
| 36–45 | 219.60 (214.04–225.28) |
3.79 (3.58–4.02) |
176.55 (170.54–182.71) |
4.44 (4.07–4.85) |
180.95 (175.53–186.49) |
4.06 (3.77–4.37) |
188.79 (183.50–194.19) |
4.04 (3.77–4.33) |
187.73 (181.45–194.17) |
3.47 (3.19–3.79) |
| 46–55 | 368.41 (361.81–375.11) |
6.36 (6.02–6.72) |
317.13 (309.37–325.02) |
7.98 (7.34–8.69) |
309.04 (302.37–315.82) |
6.93 (6.46–7.44) |
312.43 (306.07–318.88) |
6.69 (6.27–7.15) |
293.96 (286.42–301.66) |
5.44 (5.00–5.92) |
| 56–64 | 520.75 (513.27–528.32) |
8.99 (8.51–9.49) |
480.29 (470.35–490.38) |
12.08 (11.13–13.14) |
489.95 (481.09–498.93) |
10.99 (10.25–11.79) |
477.26 (469.05–485.59) |
10.22 (9.58–10.91) |
425.15 (415.20–435.28) |
7.86 (7.24–8.55) |
| DIC | 8.96 (8.48–9.47) |
5.75 (5.26–6.27) |
4.72 (4.33–5.14) |
4.84 (4.46–5.25) |
5.47 (4.97–6.00) |
|||||
| 18–25 | 3.78 (3.05–4.64) |
[ref] | 1.97 (1.33–2.82) |
[ref] | 2.01 (1.43–2.74) |
[ref] | 1.83 (1.30–2.51) |
[ref] | 3.15 (2.20–4.36) |
[ref] |
| 26–35 | 5.96 (5.01–7.04) |
1.58 (1.20–2.07) |
3.05 (2.26–4.02) |
1.55 (0.96–2.52) |
3.04 (2.32–3.93) |
1.52 (1.00–2.33) |
3.13 (2.41–4.00) |
1.71 (1.13–2.62) |
3.66 (2.77–4.74) |
1.16 (0.75–1.82) |
| 36–45 | 5.93 (5.05–6.93) |
1.57 (1.21–2.05) |
4.86 (3.91–5.97) |
2.46 (1.61–3.86) |
3.20 (2.52–4.02) |
1.60 (1.07–2.41) |
3.36 (2.69–4.15) |
1.83 (1.24–2.75) |
4.15 (3.27–5.20) |
1.32 (0.88–2.02) |
| 46–55 | 10.24 (9.17–11.41) |
2.71 (2.14–3.45) |
6.66 (5.58–7.89) |
3.38 (2.26–5.20) |
5.13 (4.30–6.06) |
2.55 (1.78–3.75) |
4.84 (4.08–5.71) |
2.64 (1.84–3.87) |
6.25 (5.19–7.46) |
1.99 (1.36–2.96) |
| 56–64 | 15.59 (14.32–16.94) |
4.12 (3.30–5.19) |
11.12 (9.66–12.75) |
5.64 (3.83–8.57) |
9.33 (8.14–10.63) |
4.65 (3.30–6.71) |
9.89 (8.74–11.15) |
5.39 (3.84–7.76) |
9.32 (7.90–10.92) |
2.96 (2.05–4.38) |
| ENC | 3.34 (3.06–3.64) |
2.11 (1.84–2.40) |
2.42 (2.15–2.70) |
2.08 (1.85–2.33) |
2.98 (2.64–3.36) |
|||||
| 18–25 | 2.88 (2.27–3.60) |
[ref] | 1.21 (0.76–1.81) |
[ref] | 1.92 (1.39–2.59) |
[ref] | 1.85 (1.35–2.48) |
[ref] | 3.40 (2.48–4.54) |
[ref] |
| 26–35 | 2.71 (2.13–3.41) |
0.94 (0.67–1.32) |
1.90 (1.36–2.58) |
1.57 (0.92–2.75) |
1.82 (1.32–2.45) |
0.95 (0.61–1.48) |
1.32 (0.91–1.85) |
0.71 (0.44–1.14) |
1.81 (1.25–2.53) |
0.53 (0.33–0.85) |
| 36–45 | 2.78 (2.21–3.45) |
0.97 (0.70–1.34) |
1.71 (1.21–2.35) |
1.42 (0.82–2.49) |
1.77 (1.30–2.35) |
0.92 (0.60–1.43) |
1.71 (1.27–2.26) |
0.93 (0.61–1.42) |
2.04 (1.47–2.76) |
0.60 (0.39–0.94) |
| 46–55 | 3.16 (2.60–3.81) |
1.10 (0.81–1.49) |
2.19 (1.63–2.87) |
1.81 (1.09–3.11) | 2.49 (1.95–3.13) |
1.29 (0.88–1.93) |
1.90 (1.45–2.43) |
1.02 (0.69–1.54) |
3.23 (2.52–4.08) |
0.95 (0.65–1.41) |
| 56–64 | 4.69 (4.03–5.43) |
1.63 (1.24–2.16) |
3.42 (2.69–4.29) |
2.84 (1.76–4.74) |
3.96 (3.23–4.80) |
2.06 (1.43–3.01) |
3.50 (2.85–4.24) |
1.89 (1.32–2.75) |
4.67 (3.73–5.79) |
1.38 (0.95–2.02) |
| GBS | 3.11 (2.83–3.42) |
2.23 (1.93–2.56) |
2.33 (2.05–2.62) |
2.24 (1.99–2.52) |
2.97 (2.61–3.37) |
|||||
| 18–25 | 1.56 (1.11–2.15) |
[ref] | 1.25 (0.75–1.95) |
[ref] | 1.65 (1.13–2.32) |
[ref] | 1.13 (0.72–1.68) |
[ref] | 2.01 (1.27–3.02) |
[ref] |
| 26–35 | 2.66 (2.04–3.41) |
1.70 (1.12–2.62) |
1.46 (0.94–2.18) |
1.17 (0.62–2.26) |
2.06 (1.47–2.81) |
1.25 (0.77–2.06) |
1.81 (1.28–2.50) |
1.61 (0.94–2.81) |
2.7 (1.94–3.64) |
1.34 (0.79–2.33) |
| 36–45 | 2.86 (2.25–3.57) |
1.83 (1.22–2.77) |
2.10 (1.50–2.88) |
1.68 (0.95–3.09) |
2.01 (1.48–2.67) |
1.22 (0.76–1.97) |
2.34 (1.79–3.02) |
2.08 (1.27–3.49) |
3.21 (2.44–4.15) |
1.60 (0.97–2.71) |
| 46–55 | 3.16 (2.57–3.83) |
2.02 (1.38–3.01) |
2.98 (2.28–3.84) |
2.39 (1.41–4.24) |
2.86 (2.26–3.59) |
1.74 (1.14–2.72) |
2.57 (2.03–3.22) |
2.28 (1.43–3.78) |
2.85 (2.15–3.70) |
1.42 (0.86–2.41) |
| 56–64 | 4.63 (3.95–5.39) |
2.96 (2.07–4.33) |
3.01 (2.27–3.91) |
2.41 (1.41–4.29) |
2.80 (2.17–3.56) |
1.70 (1.10–2.68) |
2.99 (2.37–3.71) |
2.65 (1.66–4.37) |
3.78 (2.90–4.84) |
1.88 (1.15–3.18) |
| HS | 22.98 (22.2–23.78) |
18.49 (17.60–19.40) |
16.77 (16.02–17.54) |
15.88 (15.18–16.59) |
19.64 (18.69–20.63) |
|||||
| 18–25 | 3.91 (3.16–4.78) |
[ref] | 2.83 (2.05–3.81) |
[ref] | 3.04 (2.31–3.92) |
[ref] | 3.15 (2.44–4.00) |
[ref] | 3.85 (2.80–5.16) |
[ref] |
| 26–35 | 6.95 (5.92–8.11) |
1.78 (1.37–2.32) |
5.25 (4.20–6.48) |
1.86 (1.27–2.74) |
4.64 (3.73–5.71) |
1.53 (1.09–2.16) |
4.80 (3.90–5.85) |
1.52 (1.11–2.11) |
7.12 (5.86–8.58) |
1.85 (1.29–2.69) |
| 36–45 | 14.54 (13.14–16.05) |
3.72 (2.97–4.71) |
10.58 (9.15–12.17) |
3.74 (2.68–5.33) |
8.76 (7.6–10.04) |
2.88 (2.15–3.92) |
9.49 (8.34–10.77) |
3.01 (2.29–4.01) |
12.73 (11.14–14.49) |
3.31 (2.39–4.68) |
| 46–55 | 29.1 (27.27–31.02) |
7.45 (6.03–9.30) |
23.48 (21.41–25.70) |
8.30 (6.07–11.63) |
21.56 (19.83–23.40) |
7.10 (5.43–9.45) |
20.26 (18.67–21.95) |
6.43 (4.99–8.41) |
25.87 (23.67–28.22) |
6.72 (4.94–9.37) |
| 56–64 | 47.3 (45.07–49.62) |
12.11 (9.84–15.05) |
45.42 (42.41–48.59) |
16.06 (11.82–22.36) |
40.29 (37.78–42.91) |
13.27 (10.20–17.56) |
35.47 (33.26–37.78) |
11.26 (8.79–14.65) |
42.65 (39.55–45.93) |
11.09 (8.17–15.4) |
| ITP | 39.09 (38.07–40.13) |
27.40 (26.32–28.51) |
28.67 (27.69–29.68) |
29.2 (28.25–30.16) |
34.70 (33.43–36.00) |
|||||
| 18–25 | 20.37 (18.61–22.24) |
[ref] | 13.03 (11.27–14.97) |
[ref] | 17.71 (15.89–19.68) |
[ref] | 14.48 (12.91–16.19) |
[ref] | 22.13 (19.48–25.03) |
[ref] |
| 26–35 | 38.24 (35.77–40.84) |
1.88 (1.68–2.10) |
24.42 (22.09–26.94) |
1.87 (1.58–2.23) |
24.21 (22.07–26.5) |
1.37 (1.19–1.58) |
26.65 (24.46–28.99) |
1.84 (1.60–2.12) |
30.43 (27.75–33.30) |
1.38 (1.18–1.61) |
| 36–45 | 37.45 (35.17–39.83) |
1.84 (1.65–2.05) |
26.02 (23.75–28.45) |
2.00 (1.69–2.37) |
24.79 (22.81–26.89) |
1.40 (1.22–1.60) |
27.63 (25.63–29.75) |
1.91 (1.67–2.19) |
33.29 (30.68–36.06) |
1.50 (1.30–1.75) |
| 46–55 | 42.74 (40.52–45.06) |
2.10 (1.89–2.33) |
29.06 (26.75–31.51) |
2.23 (1.90–2.63) |
31.00 (28.92–33.19) |
1.75 (1.54–1.99) |
32.44 (30.42–34.56) |
2.24 (1.97–2.56) |
36.05 (33.44–38.80) |
1.63 (1.41–1.89) |
| 56–64 | 50.33 (48.03–52.72) |
2.47 (2.24–2.74) |
41.36 (38.49–44.39) |
3.18 (2.71–3.73) |
42.44 (39.87–45.14) |
2.40 (2.12–2.72) |
40.62 (38.25–43.09) |
2.80 (2.47–3.19) |
47.43 (44.15–50.88) |
2.14 (1.86–2.48) |
| Myocarditis/pericarditis | 40.11 (39.08–41.16) |
33.75 (32.55–34.98) |
34.79 (33.71–35.90) |
34.58 (33.55–35.63) |
41.36 (39.97–42.78) |
|||||
| 18–25 | 29.87 (27.73–32.12) |
[ref] | 25.85 (23.36–28.54) |
[ref] | 28.26 (25.95–30.73) |
[ref] | 28.63 (26.41–31.00) |
[ref] | 36.21 (32.81–39.87) |
[ref] |
| 26–35 | 29.65 (27.48–31.94) |
0.99 (0.89–1.10) |
23.93 (21.62–26.42) |
0.93 (0.80–1.07) |
27.10 (24.83–29.52) |
0.96 (0.85–1.08) |
27.04 (24.83–29.39) |
0.94 (0.84–1.06) |
35.12 (32.23–38.19) |
0.97 (0.85–1.10) |
| 36–45 | 35.4 (33.19–37.72) |
1.19 (1.07–1.31) |
30.83 (28.35–33.46) |
1.19 (1.05–1.36) |
30.51 (28.31–32.83) |
1.08 (0.96–1.21) |
31.65 (29.51–33.91) |
1.11 (0.99–1.23) |
39.10 (36.27–42.09) |
1.08 (0.96–1.22) |
| 46–55 | 45.24 (42.95–47.62) |
1.51 (1.38–1.66) |
38.71 (36.04–41.53) |
1.50 (1.32–1.69) |
37.22 (34.93–39.61) |
1.32 (1.19–1.46) |
36.77 (34.62–39.03) |
1.28 (1.16–1.42) |
41.99 (39.18–44.96) |
1.16 (1.03–1.31) |
| 56–64 | 52.84 (50.48–55.28) |
1.77 (1.62–1.93) |
46.40 (43.36–49.60) |
1.79 (1.59–2.03) |
47.83 (45.10–50.69) |
1.69 (1.53–1.88) |
45.30 (42.80–47.90) |
1.58 (1.43–1.75) |
52.59 (49.14–56.22) |
1.45 (1.29–1.64) |
| Narcolepsy | 52.89 (51.70–54.09) |
41.17 (39.85–42.53) |
44.32 (43.10–45.57) |
45.53 (44.35–46.74) |
49.23 (47.72–50.78) |
|||||
| 18–25 | 60.02 (56.98–63.18) |
[ref] | 41.46 (38.29–44.83) |
[ref] | 46.25 (43.27–49.38) |
[ref] | 48.92 (46.00–51.99) |
[ref] | 66.43 (61.78–71.32) |
[ref] |
| 26–35 | 64.55 (61.33–67.90) |
1.08 (1.00–1.16) |
42.14 (39.06–45.41) |
1.02 (0.91–1.13) |
49.37 (46.29–52.61) |
1.07 (0.97–1.17) |
52.50 (49.4–55.74) |
1.07 (0.98–1.17) |
52.81 (49.26–56.54) |
0.79 (0.72–0.88) |
| 36–45 | 62.05 (59.11–65.10) |
1.03 (0.96–1.11) |
43.86 (40.89–46.98) |
1.06 (0.95–1.18) |
49.98 (47.16–52.93) |
1.08 (0.99–1.18) |
51.74 (48.99–54.60) |
1.06 (0.97–1.15) |
52.98 (49.68–56.45) |
0.80 (0.72–0.88) |
| 46–55 | 49.01 (46.62–51.48) |
0.82 (0.76–0.88) |
41.36 (38.60–44.27) |
1.00 (0.90–1.11) |
43.04 (40.58–45.62) |
0.93 (0.85–1.02) |
43.47 (41.12–45.91) |
0.89 (0.82–0.97) |
44.45 (41.55–47.50) |
0.67 (0.61–0.74) |
| 56–64 | 37.00 (35.03–39.05) |
0.62 (0.57–0.66) |
37.21 (34.49–40.09) |
0.90 (0.80–1.00) |
34.53 (32.21–36.97) |
0.75 (0.68–0.82) |
34.01 (31.84–36.27) |
0.70 (0.64–0.76) |
35.47 (32.65–38.47) |
0.53 (0.48–0.60) |
| NHS | 73.75 (72.34–75.17) |
59.93 (58.33–61.56) |
62.74 (61.29–64.22) |
57.15 (55.82–58.49) |
67.65 (65.87–69.46) |
|||||
| 18–25 | 5.39 (4.50–6.39) |
[ref] | 3.42 (2.55–4.49) |
[ref] | 4.48 (3.59–5.52) |
[ref] | 3.85 (3.07–4.78) |
[ref] | 7.26 (5.78–9.00) |
[ref] |
| 26–35 | 14.54 (13.04–16.18) |
2.70 (2.2–3.33) |
11.17 (9.61–12.91) |
3.27 (2.39–4.53) |
9.60 (8.27–11.08) |
2.14 (1.65–2.80) |
10.63 (9.26–12.14) |
2.76 (2.13–3.60) |
15.15 (13.28–17.21) |
2.09 (1.62–2.71) |
| 36–45 | 36.43 (34.19–38.79) |
6.76 (5.63–8.18) |
32.01 (29.49–34.69) |
9.36 (7.04–12.68) |
30.04 (27.86–32.34) |
6.71 (5.36–8.48) |
30.79 (28.68–33.02) |
7.99 (6.36–10.16) |
37.77 (34.99–40.71) |
5.20 (4.14–6.62) |
| 46–55 | 92.67 (89.38–96.05) |
17.20 (14.44–20.65) |
73.45 (69.75–77.30) |
21.48 (16.29–28.89) |
79.77 (76.41–83.25) |
17.82 (14.37–22.34) |
70.54 (67.54–73.64) |
18.30 (14.67–23.11) |
87.26 (83.18–91.49) |
12.02 (9.64–15.17) |
| 56–64 | 170.22 (165.96–174.56) |
31.59 (26.57–37.86) |
162.35 (156.60–168.24) |
47.47 (36.1–63.71) |
166.44 (161.3–171.69) |
37.17 (30.06–46.51) |
144.44 (139.95–149.04) |
37.47 (30.11–47.22) |
169.07 (162.83–175.48) |
23.3 (18.73–29.34) |
| PE | 179.46 (177.26–181.67) |
139.95 (137.50–142.44) |
139.64 (137.46–141.84) |
148.04 (145.90–150.20) |
169.82 (166.99–172.68) |
|||||
| 18–25 | 43.62 (41.03–46.32) |
[ref] | 29.41 (26.75–32.27) |
[ref] | 31.51 (29.06–34.11) |
[ref] | 35.17 (32.7–37.79) |
[ref] | 47.68 (43.76–51.85) |
[ref] |
| 26–35 | 88.50 (84.72–92.41) |
2.03 (1.88–2.19) |
58.20 (54.57–62.02) |
1.98 (1.77–2.22) |
61.35 (57.91–64.94) |
1.95 (1.76–2.15) |
69.36 (65.79–73.07) |
1.97 (1.80–2.16) |
85.9 (81.35–90.63) |
1.8 (1.63–1.99) |
| 36–45 | 141.96 (137.5–146.54) |
3.25 (3.04–3.49) |
111.83 (107.06–116.75) |
3.8 (3.43–4.22) |
110.07 (105.86–114.41) |
3.49 (3.20–3.82) |
117.66 (113.49–121.94) |
3.35 (3.09–3.63) |
137.11 (131.76–142.62) |
2.88 (2.62–3.16) |
| 46–55 | 229.26 (224.06–234.55) |
5.26 (4.93–5.61) |
186.41 (180.48–192.48) |
6.34 (5.74–7.01) |
178.87 (173.81–184.04) |
5.68 (5.22–6.19) |
189.69 (184.75–194.73) |
5.39 (5–5.83) |
215.54 (209.09–222.14) |
4.52 (4.13–4.95) |
| 56–64 | 315.28 (309.47–321.17) |
7.23 (6.79–7.71) |
280.65 (273.08–288.38) |
9.54 (8.66–10.53) |
276.91 (270.27–283.68) |
8.79 (8.09–9.56) |
279.75 (273.48–286.13) |
7.95 (7.38–8.59) |
316.35 (307.78–325.09) |
6.64 (6.07–7.26) |
| TM | 1.96 (1.74–2.21) |
1.41 (1.17–1.68) |
1.57 (1.35–1.82) |
1.28 (1.08–1.49) |
1.61 (1.35–1.91) |
|||||
| 18–25 | 1.15 (0.77–1.66) |
[ref] | 0.59 (0.27–1.12) |
[ref] | 0.98 (0.59–1.53) |
[ref] | 0.80 (0.47–1.28) |
[ref] | 1.49 (0.87–2.38) |
[ref] |
| 26–35 | 1.59 (1.12–2.19) |
1.38 (0.82–2.34) |
1.46 (0.94–2.18) |
2.47 (1.11–6.05) |
1.39 (0.92–2.03) |
1.42 (0.76–2.71) |
1.13 (0.71–1.69) |
1.41 (0.72–2.81) |
1.09 (0.64–1.75) |
0.73 (0.35–1.53) |
| 36–45 | 2.26 (1.73–2.91) |
1.96 (1.24–3.19) |
1.13 (0.70–1.73) |
1.91 (0.84–4.75) |
1.45 (1.01–2.03) |
1.49 (0.82–2.76) |
1.21 (0.82–1.72) |
1.52 (0.81–2.92) |
1.77 (1.21–2.50) |
1.19 (0.64–2.29) |
| 46–55 | 2.23 (1.74–2.81) |
1.94 (1.23–3.11) |
1.94 (1.38–2.65) |
3.28 (1.56–7.69) |
1.85 (1.37–2.44) |
1.89 (1.09–3.4) |
1.56 (1.14–2.08) |
1.95 (1.10–3.63) |
1.78 (1.24–2.47) |
1.2 (0.65–2.28) |
| 56–64 | 2.30 (1.83–2.85) |
2.00 (1.29–3.18) |
1.72 (1.18–2.43) |
2.91 (1.36–6.92) |
2.01 (1.48–2.66) |
2.05 (1.18–3.7) |
1.51 (1.09–2.05) |
1.89 (1.05–3.55) |
1.83 (1.23–2.61) |
1.23 (0.66–2.38) |
| Unusual site TTS | 3.80 (3.49–4.14) |
3.04 (2.69–3.42) |
2.17 (1.91–2.46) |
2.02 (1.78–2.28) |
2.92 (2.56–3.32) |
|||||
| 18–25 | 0.90 (0.57–1.37) |
[ref] | 0.79 (0.41–1.38) |
[ref] | 0.21 (0.06–0.53) |
[ref] | 0.33 (0.13–0.68) |
[ref] | 0.79 (0.36–1.49) |
[ref] |
| 26–35 | 1.80 (1.30–2.44) |
1.99 (1.16–3.50) |
0.43 (0.17–0.88) |
0.54 (0.18–1.49) |
0.93 (0.55–1.47) |
4.51 (1.49–18.33) |
0.54 (0.27–0.96) |
1.64 (0.58–4.98) |
0.77 (0.40–1.35) |
0.98 (0.38–2.63) |
| 36–45 | 2.45 (1.89–3.11) |
2.71 (1.65–4.60) |
1.35 (0.87–1.99) |
1.71 (0.83–3.73) |
1.58 (1.11–2.18) |
7.68 (2.76–29.65) |
1.52 (1.08–2.08) |
4.63 (2.05–12.27) |
2.49 (1.82–3.33) |
3.17 (1.53–7.37) |
| 46–55 | 4.55 (3.84–5.35) |
5.03 (3.20–8.27) |
3.98 (3.15–4.95) |
5.04 (2.73–10.16) |
2.71 (2.12–3.42) |
13.18 (4.93–49.69) |
2.30 (1.79–2.92) |
7.00 (3.22–18.07) |
3.46 (2.68–4.38) |
4.39 (2.18–10.01) |
| 56–64 | 7.43 (6.56–8.38) |
8.21 (5.31–13.33) |
7.85 (6.63–9.23) |
9.94 (5.52–19.68) |
4.77 (3.93–5.73) |
23.16 (8.80–86.46) |
4.61 (3.84–5.5) |
14.02 (6.61–35.58) |
6.27 (5.12–7.61) |
7.97 (4.04–17.93) |
| Common site TTS | 35.22 (34.25–36.21) |
28.25 (27.15–29.38) |
22.89 (22.01–23.79) |
22.74 (21.91–23.59) |
30.47 (29.28–31.69) |
|||||
| 18–25 | 6.17 (5.22–7.24) |
[ref] | 3.95 (3.01–5.08) |
[ref] | 4.63 (3.72–5.69) |
[ref] | 4.42 (3.57–5.41) |
[ref] | 8.13 (6.56–9.96) |
[ref] |
| 26–35 | 10.42 (9.15–11.82) |
1.69 (1.37–2.09) |
7.75 (6.46–9.22) |
1.96 (1.43–2.72) |
6.66 (5.56–7.91) |
1.44 (1.09–1.90) |
7.88 (6.71–9.20) |
1.78 (1.38–2.33) |
8.28 (6.91–9.84) |
1.02 (0.77–1.34) |
| 36–45 | 18.88 (17.28–20.60) |
3.06 (2.55–3.70) |
14.14 (12.48–15.96) |
3.58 (2.70–4.83) |
12.39 (11.00–13.90) |
2.67 (2.10–3.43) |
12.31 (10.98–13.74) |
2.79 (2.21–3.55) |
17.94 (16.04–20.00) |
2.21 (1.75–2.81) |
| 46–55 | 43.13 (40.89–45.45) |
6.99 (5.90–8.33) |
34.62 (32.10–37.30) |
8.77 (6.73–11.62) |
26.88 (24.94–28.93) |
5.80 (4.66–7.31) |
26.63 (24.8–28.56) |
6.03 (4.86–7.55) |
36.49 (33.87–39.26) | 4.49 (3.61–5.63) |
| 56–64 | 76.43 (73.59–79.36) |
12.39 (10.51–14.70) |
73.34 (69.50–77.34) |
18.58 (14.35–24.49) |
56.74 (53.76–59.84) |
12.25 (9.89–15.34) |
53.93 (51.2–56.77) |
12.21 (9.90–15.20) |
73.68 (69.58–77.95) |
9.06 (7.33–11.31) |
| CD, in thousandsb | 2.82 (2.81–2.83) |
2.08 (2.07–2.09) |
2.34 (2.34–2.35) |
2.34 (2.33–2.35) |
N/A | |||||
| 18–25 | 0.07 (0.06–0.07) |
[ref] | 0.06 (0.05–0.06) |
[ref] | 0.07 (0.07–0.07) |
[ref] | 0.07 (0.06–0.07) |
[ref] | N/A | N/A |
| 26–35 | 0.28 (0.28–0.29) |
4.23 (4.00–4.46) |
0.22 (0.21–0.23) |
3.77 (3.50–4.06) |
0.26 (0.25–0.26) |
3.73 (3.51–3.97) |
0.26 (0.25–0.26) |
3.90 (3.68–4.14) |
N/A | N/A |
| 36–45 | 0.95 (0.94–0.96) |
14.13 (13.44–14.86) |
0.74 (0.72–0.75) |
12.65 (11.81–13.55) |
0.86 (0.84–0.87) |
12.46 (11.79–13.18) |
0.83 (0.82–0.84) |
12.56 (11.90–13.26) |
N/A | N/A |
| 46–55 | 4.13 (4.11–4.15) |
61.48 (58.55–64.60) |
3.26 (3.24–3.29) |
56.05 (52.45–59.96) |
3.61 (3.59–3.63) |
52.53 (49.77–55.49) |
3.54 (3.52–3.56) |
53.62 (50.86–56.56) |
N/A | N/A |
| 56–64 | 6.90 (6.87–6.92) |
102.62 (97.76–107.78) |
5.65 (5.61–5.68) |
97.11 (90.89–103.88) |
6.22 (6.18–6.25) |
90.49 (85.74–95.58) |
6.09 (6.06–6.12) |
92.16 (87.44–97.20) |
N/A | N/A |
| HTN, in thousandsb | 10.37 (10.35–10.39) |
7.80 (7.78–7.82) |
8.99 (8.97–9.01) |
9.44 (9.42–9.46) |
N/A | |||||
| 18–25 | 1.22 (1.21–1.24) |
[ref] | 0.94 (0.92–0.96) |
[ref] | 1.11 (1.10–1.13) |
[ref] | 1.12 (1.11–1.14) |
[ref] | N/A | N/A |
| 26–35 | 3.93 (3.90–3.96) |
3.21 (3.17–3.25) |
2.77 (2.74–2.79) |
2.94 (2.89–3.00) |
3.39 (3.37–3.42) |
3.05 (3.00–3.1) |
3.57 (3.54–3.60) |
3.18 (3.13–3.23) |
N/A | N/A |
| 36–45 | 8.06 (8.02–8.1) |
6.58 (6.50–6.66) |
6.33 (6.29–6.37) |
6.73 (6.62–6.85) |
7.33 (7.30–7.37) |
6.59 (6.5–6.69) |
7.51 (7.48–7.55) |
6.69 (6.60–6.79) |
N/A | N/A |
| 46–55 | 16.15 (16.09–16.2) |
13.19 (13.04–13.34) |
12.57 (12.51–12.62) |
13.37 (13.14–13.60) |
14.23 (14.18–14.28) |
12.79 (12.62–12.96) |
14.74 (14.69–14.79) |
13.13 (12.96–13.3) |
N/A | N/A |
| 56–64 | 24.54 (24.47–24.61) |
20.04 (19.82–20.27) |
19.25 (19.17–19.33) |
20.47 (20.14–20.82) |
22.15 (22.08–22.23) |
19.91 (19.65–20.18) |
23.03 (22.96–23.11) |
20.52 (20.26–20.78) |
N/A | N/A |
| WCV, in thousandsb | 69.73 (69.69–69.77) |
50.23 (50.19–50.28) |
53.47 (53.43–53.51) |
60.41 (60.37–60.45) |
N/A | |||||
| 18–25 | 51.23 (51.14–51.32) |
[ref] | 35.26 (35.16–35.35) |
[ref] | 35.56 (35.48–35.65) |
[ref] | 41.76 (41.67–41.84) |
[ref] | N/A | N/A |
| 26–35 | 60.91 (60.81–61.01) |
1.19 (1.19–1.19) |
44.00 (43.90–44.10) |
1.25 (1.24–1.25) |
45.07 (44.97–45.16) |
1.27 (1.26–1.27) |
52.11 (52.01–52.2) |
1.25 (1.25–1.25) |
N/A | N/A |
| 36–45 | 69.56 (69.46–69.66) |
1.36 (1.36–1.36) |
51.93 (51.83–52.04) |
1.47 (1.47–1.48) |
53.77 (53.68–53.87) |
1.51 (1.51–1.52) |
61.06 (60.97–61.16) |
1.46 (1.46–1.47) |
N/A | N/A |
| 46–55 | 77.44 (77.34–77.54) |
1.51 (1.51–1.51) |
57.33 (57.22–57.43) |
1.63 (1.62–1.63) |
61.17 (61.08–61.27) |
1.72 (1.72–1.72) |
68.74 (68.65–68.83) |
1.65 (1.64–1.65) |
N/A | N/A |
| 56–64 | 81.25 (81.16–81.34) |
1.59 (1.58–1.59) |
58.59 (58.48–58.70) |
1.66 (1.66–1.67) |
65.97 (65.87–66.07) |
1.85 (1.85–1.86) |
71.62 (71.52–71.72) |
1.72 (1.71–1.72) |
N/A | N/A |
Abbreviations: AESI, adverse event of special interest; AMI, acute myocardial infarction; BHI, Blue Health Intelligence; CD, colonic diverticulitis; CI, confidence interval; DIC, disseminated intravascular coagulation; DVT, deep vein thrombosis; ENC, encephalitis/encephalomyelitis; GBS, Guillain-Barré syndrome; HS, hemorrhagic stroke; HTN, hypertension; IR, incidence rate; IRR, incidence rate ratio; ITP, immune thrombocytopenia; N/A, not available; NHS, non-hemorrhagic stroke; PE, pulmonary embolism; PY, person-years; ref, reference; TM, transverse myelitis; TTS, thrombosis with thrombocytopenia syndrome; WCV, well-care visit.
a
Analyses and results for negative control events are not available for Optum.
b
Incidence rates of negative control events are reported in thousands (e.g., a value of 1 corresponds to a rate of 1,000 per 100,000 person-years).