TABLE 1.
The binding information of hCD82 with TGFRI, TGFRII, integrin αv and integrin β1.
| Complex | Binding site | ||
|---|---|---|---|
| CD82/TGFRI | TGFRI (AF ID: P36897) | hCD82 (AF ID: P277701) | Distance (Å) |
| Arg 237 | Gln 225 | 3.5 | |
| Glu 238 | Leu 224 | 3.0 | |
| Lys 337 | Gln 146 | 3.1 | |
| Val 432 | Asn 184 | 2.6 | |
| Val 432 | Asn 184 | 2.3 | |
| CD82/TGFRII | TGFRII (AF ID: P37173) | hCD82 (AF ID: P277701) | Distance (Å) |
| Arg 339 | Glu 218 | 2.5 | |
| Asp 469 | Thr 122 | 2.3 | |
| Asp 469 | Asn 157 | 2.3 | |
| Asp469 | Asn 157 | 1.9 | |
| Val 467 | Asp 160 | 2.4 | |
| Glu 466 | Asp 160 | 3.4 | |
| Glu 466 | Asp160 | 2.7 | |
| CD82/Integrin αv | Integrin αv (PDB ID: 6AVR) | hCD82 (AF ID: P277701) | Distance (Å) |
| Thr 212 | Asn 184 | 3.5 | |
| Ala 213 | Asn 184 | 1.9 | |
| Asp 218 | Tyr 142 | 3.2 | |
| Ala 246 | Tyr 142 | 2.4 | |
| Asn 266 | Asn 227 | 3.3 | |
| CD82/Integrin β1 | Integrin β1 (PDB ID: 3VI4) | hCD82 (AF ID: P277701) | Distance (Å) |
| Val 274 | Gln 115 | 3.5 | |
| Gly 272 | Gly 118 | 3.3 | |
| His 292 | Asn 157 | 3.0 | |
| Thr 289 | Asp160 | 2.5 | |
| Thr 178 | Gln 213 | 2.3 | |
The complexes of hCD82/TGFRI, hCD82/TGFRII, hCD82/integrin β1, and hCD82/integrin αv were bound, and the most stable complex was obtained from the ZDOCK, server. The interacting residues and distances of covalent binding for hCD82/TGFR, and hCD82/integrin complexes are presented.