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. 2022 Nov 7;13(11):935. doi: 10.1038/s41419-022-05388-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The efficiency of SIRT2 shRNA lentivirus infection in MG63 cells was observed under a fluorescence microscope. B Western blot was used to detect SIRT2 expression after SIRT2 shRNA infection of MG63 cells. C The tumor growth curve of nude mice subcutaneously injected with MG63-shSIRT2 and control cells. D The tumors of the nude mice in the two groups were isolated and photographed. E The tumors in the nude mice were weighed and compared. F H&E staining of tumor tissues. Data from one pair of representative staining of 6 tumor tissues are shown. G The EMT-related proteins were detected in the tumors of the two groups. Data from one representative experiment of three are shown. (*P < 0.05, **P < 0.01, ***P < 0.001).