Fig. 1. LINC01468 is especially upregulated in liver tissues during NAFLD-HCC.
A Heatmap summarizing RNA-Seq data for human HCC with or without NAFLD with 5944 upregulated genes (pink) and 104 downregulated genes (green). B Overlapping of the 17 genes significantly altered in both human (n = 3) and mice (n = 3) NAFLD-HCC (P < 1.78 × 10−9). C Part of the genes described in B. D qRT-PCR was used to assess the relative expression levels of four lncRNAs in 26 paired peritumoral tissues and HCC tissues (**P < 0.01). E qRT-PCR was used to determine the levels of lipogenic enzymes and prolipogenic transcription factor in 26 paired HCC tissues and peritumoral tissues. F Representative immunoblotting results for the major lipogenesis protein with or without the indicated LncRNA overexpression in Huh7 cell line. G Scatter-plot analysis of the correlation between the mRNA levels of LINC01468 and SREBP1 or ACLY in 26 HCC tissues. H Kaplan–Meier analysis of the correlation of LINC01468 expression with overall survival.