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. 2022 Nov 7;8:449. doi: 10.1038/s41420-022-01234-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Differently expressed genes in SNU-449 cells transfected with shLINC01468 or control were shown by heatmap. B KEGG pathway analysis of LINC01468-regulated genes. C KEGG pathway enrichment analysis of target genes by a bubble chart. The size and color of the dots represents the number and level of genes that were enriched in the corresponding pathways, respectively. D The item was enriched using GSEA in SUN-449 cells transfected with shLINC01468 or control. E, F Immunoblot detection of Akt/mTOR signaling pathway protein level in E LINC01468-knockdown SNU-449 cells or F LINC01468-overexpressed Huh7 cells. G Immunoblotting of the indicated protein lysates from Huh7 cells expressing Ctrl or LINC01468 treated with or without rapamycin (Rapa). H The intracellular lipid droplets in SUN-449 cells transfected with shLINC01468 or control were stained with oil red O. I The cellular content of triglycerides and phospholipids in the indicated cells in H was detected. J Representative liver images (top), H&E staining (middle), and ORO staining (bottom) of xenografts derived from SUN-449 cells stably transfected with the scrambled control or siLINC01468. K–M Overexpression of LINC01468 increased tumor growth and mediated sorafenib resistance of HCC tumors in nude mice. Images show representative tumor (K). Growth curves (L) and tumor weights (M) of mean ± SD of six mice in each group.***P < 0.005; ****P < 0.001.