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. 2022 Oct 25;9:1012827. doi: 10.3389/fmed.2022.1012827

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Copyright © 2022 Casanova, Reyes-Hernon, Gregory, Sun, Bermudez, Hufford, Oita, Camp, Hernandez-Molina, Serrano, Sun, Fimbres, Mirsaeidi, Sammani, Bime and Garcia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biomarker plasma levels in sarcoidosis and healthy controls. Plasma levels medians are plotted. Compared to healthy controls, each biomarker exhibited higher values in plasma of sarcoidosis patients. Except for IL-8 all of plasma biomarkers were significantly higher in sarcoidosis. eNAMPT (2.1 vs. 1.2 ng/ml), IL-6 (1.2 vs. 0.6 pg/ml), ANG-2 (2.7 vs. 1.0 pg/ml), HBEGF (5.9 vs. 1 pg/ml), and IL-1 RA (227 vs. 82.3 pg/ml). Mann–Whitney test was calculated for each comparison; ****p-values < 0.0001 and *p < 0.05.