TABLE 3.

Biomarker plasma levels in sarcoidosis.

Biomarker	N	Median (Q1, Q3)	Sarcoidosis vs. control P-value*	Sarcoidosis/pulmonary fibrosis (n = 19) P-value**	Complicated sarcoidosis (n = 62) P-value***
eNAMPT (ng/ml)	123	2.1 (1.4,4.3)	<0.0001	0.2	0.5153
IL-6 (pg/ml)	123	1.2 (0.8, 1.8)	<0.0001	0.18	0.17
IL-8 (pg/ml)	123	3.1 (1.7, 5.3)	0.51	0.7	0.18
IL-1RA (pg/ml)	123	228 (163, 418)	<0.0001	0.18	0.35
ANG-2 (ng/ml)	123	2.7 (1.7, 4)	<0.0001	0.017	0.4
HBEGF (pg/ml)	68	5.9 (1, 39.5)	0.026	0.028	0.003

Summary statistics and P-values from Mann–Whitney test comparing all markers plasma measurements in sarcoidosis vs. healthy controls*; sarcoidosis with pulmonary fibrosis (stage IV) vs. sarcoidosis without pulmonary involvement (stages I and II) ** and complicated sarcoidosis vs. non-complicated sarcoidosis ***. Lung fibrosis is bolded to indicate is an important category, in which the analysis was based.