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. 2022 Nov 7;13(11):932. doi: 10.1038/s41419-022-05390-8

Fig. 7. Gene therapy with circFOXO3 preserves articular cartilage integrity in a mouse OA model.

Fig. 7

A Schematic of the animal experiments (for each group, n = 6, C57BL/6). B X-ray and 3D reconstruction images of micro- CT scanning of the knees. Scale bars, 2 mm and 1 mm. C OARSI scoring was performed according to staining results. (n = 6) *p < 0.05. D Safranin-O/fast green staining, H&E staining, TUNEL staining, IHC staining and IF staining of cartilage from different groups. Scale bars, 20 μm. E Safranin-O/fast green staining, H&E staining, TUNEL staining and IHC staining of cartilage from different groups. Scale bars, 20 μm. F Graphic abstract of our study.