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. 2022 Nov 7;13:6719. doi: 10.1038/s41467-022-34378-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Binding of the ωRNA and target DNA to the IscB protein. IscB is shown as a surface model. GAH guide adaptor hairpin, NS nexus stem, CS central stem, SL2 stem loop 2, NPKH nexus pseudoknot hairpin, NPKS nexus pseudoknot stem, LNK linker, TH1 terminal hairpin 1, TH2 terminal hairpin 2. b Indel activities of the wild-type (WT) and mutant IscB proteins. ΔREC is the REC mutant in which residues 129–144 were replaced with a GGGS linker. Data are mean ± s.e.m. (n = 4, biologically independent samples). The experiments were repeated four times with similar results. Source data are provided as a Source Data file. c–e Recognition of the seed region (c, d) and the TAM (e). Hydrogen bonds are shown as dashed lines.