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. 2022 Nov 7;22(2):101–126. doi: 10.1038/s41573-022-00579-0

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Fig. 4 — a, Structure of HER2–CD3 bispecific antibody with ‘knobs-in-hole’ technology. b, Mechanism of action of a HER2–CD3 bispecific antibody. Step 1: binding of HER2–CD3 bispecific antibody to HER2 on tumour cell and CD3 on T cell. Step 2: activation of T cell causing release of cytokines (TNF and interferon-γ (IFNγ)). Step 3: tumour cell lysis.