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. 2022 Oct 25;12:1023606. doi: 10.3389/fonc.2022.1023606

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Copyright © 2022 Jia and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PAX5 rearrangements in B-ALL. The summary of PAX5 rearrangements is based on the result from the 1,988 B-ALL cohort (16). (A) Distribution of PAX5 fusion partners. The fusion partners observed in at least 2 B-ALL cases are annotated in the pie chart, and the singletons are merged into the “other” group. (B) Scheme of PAX5 rearrangements with recurrent partner genes. The most common isoform of each fusion is shown. The green bars indicate the remaining part of the PAX5 protein. The starting amino acid (aa) of the fusion partners are annotated in parentheses. All the rearrangements reserve the paired box DNA binding domain of PAX5, except the fusions with ZCCHC7, a proximal gene commonly fused with PAX5 by focal deletion.