Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 7;26:344. doi: 10.1186/s13054-022-04193-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Urinary peptidome changes during CBP-surgery-induced AKI. A. Peptides with significantly different abundances in AKI patients. The volcano plot displays log10-transformed and adjusted univariate p values as a function of log2-transformed fold changes of urinary peptides amplitudes. Sequenced peptides with differential abundances (significant after Benjamini–Hochberg adjusted Wilcoxon univariate testing (p < 0.05)) are represented in color (more abundant: red; less abundant: blue). B. Peptides with significantly different abundances (in respect to distribution frequency and amplitude signal) derived from non-collagenic proteins (y position), log2 fold changes (x position), and –log10 adjusted p values (color scale). The brown dashed line represents log2 fold change = 0. Peptides are ranked according to their functional role during the AKI progression (inflammation, epithelium, blood component, other non-collagenic proteins). C. Peptides with significantly different abundances derived from collagenic proteins (y position), log2 fold changes (x position), and –log10 adjusted p values (color scale). The brown dashed line represents log2 fold change = 0. D. Collagenic and non-collagenic proteins-derived peptides proportions among top differential peptides according to the Benjamini–Hochberg adjusted p value ranking. The red line corresponds to non-collagen and the blue line to collagen-derived peptides