Table 4.

Relationship between AST/ALT ratio and the incident prediabetes in different models.

Variable	Non-adjusted model (HR.,95% CI, P)	Minimally-adjusted model (HR,95% CI, P)	Fully-adjusted model (HR,95% CI, P)	GAM(HR,95% CI, P)
Total AST/ALT ratio	0.59 (0.57, 0.62) <0.0001	0.76 (0.72, 0.81) <0.0001	0.79 (0.75, 0.84) <0.0001	0.79 (0.75, 0.84) <0.0001
AST/ALT ratio (quartile)
Q1	ref	ref	ref	ref
Q2	0.80 (0.76, 0.84) <0.0001	0.85 (0.81, 0.90) <0.0001	0.86 (0.81, 0.90) <0.0001	0.85 (0.80, 0.90) <0.0001
Q3	0.68 (0.64, 0.72) <0.0001	0.82 (0.77, 0.87) <0.0001	0.84 (0.79, 0.90) <0.0001	0.84 (0.79, 0.89) <0.0001
Q4	0.55 (0.52, 0.59) <0.0001	0.75 (0.70, 0.80) <0.0001	0.78 (0.72, 0.83) <0.0001	0.78 (0.73, 0.84) <0.0001
P for trend	<0.0001	<0.0001	<0.0001	<0.0001

Crude model: we did not adjust for other covariants.

Minimally-adjusted model: we adjusted for gender, age, family history of diabetes, drinking status, smoking status, SBP, DBP, BMI.

Fully-adjusted model: we adjusted for gender, age, family history of diabetes, drinking status, smoking status, SBP, DBP, BMI, TC, TG, HDL-C, LDL-C, SCr, BUN, FPG.

GAM: All covariates listed in Table 1 were adjusted. However, continuous covariates were adjusted as nonlinearity.

HR, hazard ratios; CI, confidence interval; Ref, reference; GAM, generalized additive mode; AST/ALT ratio, aspartate aminotransferase to alanine aminotransferase ratio.