TABLE 4.

Subgroup analysis of overall survival in age.

	Subgroup analysis	HR	95%CI	p
< 65 years	First line	0.80	0.74–0.86	<0.001
	Non-first line	0.82	0.68–0.98	0.028
≥ 65 years	First line	0.81	0.73–0.90	<0.001
	Non-first line	0.77	0.62–0.96	0.019
< 65 years	PD-1/PD-L1 + Chemotherapy vs. Chemotherapy	0.77	0.71–0.84	<0.001
	PD-1/PD-L1 vs. Chemotherapy	0.84	0.75–0.95	0.004
≥ 65 years	PD-1/PD-L1 + Chemotherapy vs. Chemotherapy	0.77	0.67–0.88	<0.001
	PD-1/PD-L1 vs. Chemotherapy	0.83	0.72–0.95	0.009
< 65 years	E + GEJ	0.75	0.68–0.82	<0.001
	G + GEJ	0.87	0.77–0.98	0.022
≥ 65 years	E + GEJ	0.74	0.66–0.84	<0.001
	G + GEJ	0.87	0.74–1.03	0.100