TABLE 5.

Subgroup analysis of overall survival in sex.

	Subgroup analysis	HR	95%CI	p
Male	First line	0.77	0.71–0.84	<0.001
	Non-first line	0.78	0.67–0.91	0.002
Female	First line	0.92	0.82–1.03	0.153
	Non-first line	0.89	0.66–1.21	0.461
Male	PD-1/PD-L1 + Chemotherapy vs. Chemotherapy	0.73	0.66–0.81	<0.001
	PD-1/PD-L1 vs. Chemotherapy	0.82	0.74–0.90	<0.001
Female	PD-1/PD-L1 + Chemotherapy vs. Chemotherapy	0.90	0.79–1.03	0.141
	PD-1/PD-L1 vs. Chemotherapy	0.94	0.79–1.11	0.469
Male	E + GEJ	0.73	0.66–0.80	<0.001
	G + GEJ	0.84	0.75–0.95	0.004
Female	E + GEJ	0.87	0.70–1.06	0.171
	G + GEJ	0.99	0.87–1.14	0.906