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. 2022 Oct 25;13:925377. doi: 10.3389/fphar.2022.925377

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Copyright © 2022 Yang, Lv, Yu, Mei, Xiang, Zhao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thyroid neoplasm reporting rates. The reporting rates of GLP-1RA-associated neoplasms were compared with different comparators in four models: 1) other drugs excluding GLP-1RA (non-GLP-1RA) without indication restrictions; 2) non-GLP-1RA when diabetes as an indication; 3) non-GLP-1RA when the indication is limited to diabetes while excluding all tumors, and all cases with GLP-1RA as the “primary suspect” drug; and 4) all cases combining other glucose-lowering drugs were excluded on the basis of model 3 for comparison.