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. 2022 Sep 26;17:100441. doi: 10.1016/j.mtbio.2022.100441

Table 3.

PDT performance of various NIR probes supported by existing literature [68,71].

Photosensitizer Performance Application Indication
The porphyrin-HDL nanoparticle (PLP) [68] Providing a safe, minimally invasive, and effective alternative to thyroidectomy for TC therapies PLP-PDT enabled complete ablation of tumor tissue while sparing both the normal thyroid tissue and RLN from damage. DTC
Hypericin (HYP) [71] HYP, isolated from St. John's wort (Hypericum perforatum L), is regarded as a powerful photosensitizer, which is studied for its photodynamic effects. HYP-assisted PDT can promote mitochondrial damage and cell apoptosis in adenocarcinoma, liver cancer, and vascular malformation cells. ATC
B–OMe-NPs [55] B–OMe-NPs and laser irradiation mediated therapy and cell proliferation inhibition lead to tumor tissue damage It has good photostability and effective photoacoustic imaging and fluorescence imaging ability, and combines PTT and PDT treatment modes Cancer