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. 2022 Oct 25;13:1015161. doi: 10.3389/fgene.2022.1015161

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Copyright © 2022 Palmieri, Zulato, Wahl, Guibert and Frullanti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paired Forest plot of PLR and NLR of cfDNA testing in detecting KRAS mutation in NSCLC for 39 studies in the meta-analysis. Random-effects (RE) model used. The square and horizontal bars represented study-specific PLR and NLR and 95% confidence interval (CI). Squares in different colors represent a different diagnostic method (red = Targeted NSG; blue = ddPCR; yellow = both; black = other method). Diamonds represented the overall results. The pooled PLR and NLR were 8.32 (95% CI 6.93–9.99) and 0.29 (95% CI 0.26–0.33), respectively.