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Infant rat model of meningococcal infection
| Parameter | MC58
|
2120
|
||||
|---|---|---|---|---|---|---|
| Wild type | lst | galE | Wild type | lst | galE | |
| Infective dose [log10(CFU)/ animal] | 6.32 | 6.37 | 5.58 | 6.67 | 6.49 | 6.66 |
| n | 9 | 8 | 4 | 7 | 7 | 4 |
| Log10(CFU)/ ml of blooda | 4.97 ± 0.28 | 4.80 ± 0.29 | <1.0 | 4.63 ± 0.70 | 3.39 ± 0.49 | <1.0 |
| Pb | 0.25 | 0.002 | ||||
The limit of detection was 1.0 CFU/ml of blood.
Log10(CFU)/ml of blood values were compared by Student’s t test. Differences were considered significant at P of <0.01.
