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Literature data support sigmoid dose-response models
(A) Correlation of fit for seven studies with n > 4 mice/dose 27,28,29,30,31,32 showing actual data versus predicted data with a sigmoid dose-response curve fit. (B) Parameter results for the log(EC50) from each study. Bars represent mean ± SD for all experiments in each study (average no. of experiments for each study = 2). (C) Correlation parameter (SSE) as a function of the dose span used for each experiment.
