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. 2022 Oct 21;27:368–379. doi: 10.1016/j.omtm.2022.10.011

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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In vitro dose response measured using a dynamic culture system

(A) In vitro perfusion culture system allows for dynamic measurements of transgenic protein secretion rate from AAV-transduced cells. (B) In vitro concentration of GLuc (black) and transduction efficiency as measured by GFP+ cell number (pink) as a function of dose. (C) Calculated secretion rate as a function of dose. Black curve: sigmoid dose-response model Hill equation. Dotted line: 95% confidence interval. Data points show ± SD for n = 7 steady-state concentrations per well. Blue line: EC₅₀.