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. 2022 Oct;11(10):3610–3619. doi: 10.21037/tcr-22-589

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The MFN2 expression detected by immunohistochemistry and single cell RNA-seq analysis of the colon cancer. (A,B) Representative immunohistochemical staining in colon normal tissues (A) and colon cancer tissues (B). The red arrow indicates the stained area of the gland. (C) From dataset GSE139555, an t-SNE plot showing 11 cell clusters (up) and MFN2 expression levels in various clusters (down). (D) The t-SNE plot showing 9 cell clusters (up) and expression levels of MFN2 in different clusters from dataset GSE146771 (down). MFN2, mitofusin 2; CRC, colorectal cancer; RNA-seq, RNA sequencing; t-SNE, t-distributed stochastic neighbor embedding; CD4Tconv, conventional CD4⁺ T cells; CD8T, CD8 T lymphocytes; CD8Tex, exhausted CD8 T cells; Mono/Macro, monocyte/macrophage; NK, natural killer; Tprolif, proliferative T cells; Treg, regulatory CD4⁺ T cell.