Table 2. COX analysis of the associations between MAN2A1 expression and clinicopathologic features of CRC patients in TCGA database.
| Parameter | Univariate analysis | ||
|---|---|---|---|
| P value | HR | 95% CI | |
| Age (≥65 vs. <65), years | 0.001** | 1.984 | 1.34–2.938 |
| Gender (female vs. male) | 0.847 | 0.966 | 0.682–1.370 |
| Invasion depth (T3 & T4 vs. T1 & T2) | 0.005 | 2.444 | 1.314–4.547 |
| Lymph node metastasis (yes vs. no) | <0.001*** | 2.509 | 1.749–3.599 |
| Distant metastasis (yes vs. no) | <0.001*** | 3.766 | 2.551–5.561 |
| TNM stage (stages III & IV vs. Stages I & II) | <0.001*** | 2.832 | 1.936–4.143 |
| MAN2A1 expression (high vs. low) | 0.013 | 0.637 | 0.446–0.909 |
| Pharmacological treatment (yes vs. no) | 0.731 | 1.089 | 0.670–1.770 |
| Radiation treatment (yes vs. no) | 0.047 | 0.592 | 0.353–0.992 |
**, P<0.01; ***, P<0.001. CRC, colorectal cancer; TCGA, The Cancer Genome Atlas; HR, hazard ratio; TNM, Tumor Node Metastasis.