Figure 6. (A) section of kidney control group (Group I) of rat shows a Normal looking cortex, the glomeruli are with in normal (yellow arrow) no congestion of their capillaries, the urinary space is not dilated (green arrow), and the interstitial shows no congestion (pink arrow) (H&E ×40). (B) The kidney tissue section of rat treated with methotrexate for 4 days (group II) shows severe glomeruli congestion (Yellow arrow) and atrophy with widening of the urinary space (green arrow), (green arrow), severe congestion is also observed in the interstitial (pink arrow) (H&E ×40).