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. 2022 Oct 25;10:1016955. doi: 10.3389/fcell.2022.1016955

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Copyright © 2022 Rodriguez-Casanova, Costa-Fraga, Castro-Carballeira, González-Conde, Abuin, Bao-Caamano, García-Caballero, Brozos-Vazquez, Rodriguez-López, Cebey, Palacios, Cueva, López-López, Costa and Díaz-Lagares.

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Methylation landscape of cell-free DNA in metastatic patients with luminal B breast cancer. (A) Flowchart of the cfDNA methylation analysis. Individual cfDNA samples from controls and luminal B breast cancer patients were analyzed with EPIC array. (B–G) Description of the 28,799 differentially methylated CpGs (DMCpGs) found in cfDNA of luminal B breast cancer patients according to (B) chromosome location, (C) methylation status, (D,F) CpG context, and (E,G) gene location. cfDNA, cell-free DNA; Ctrls, controls; LBBC, luminal B breast cancer; FDR, false discovery rate; HypoM, hypomethylated; HyperM, hypermethylated.