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. 2022 Oct 25;10:1016955. doi: 10.3389/fcell.2022.1016955

FIGURE 2.

FIGURE 2

Episignature of cell-free DNA in metastatic patients with luminal B breast cancer. (A) Unsupervised hierarchical clustering heatmap of the episignature (1,467 DMCpGs) obtained in cfDNA that differentiates LBBC patients (n = 7) from nontumor controls (n = 5). (B) Gene Ontology enrichment analysis by the PANTHER database, showing the most representative pathways associated with the episignature of cfDNA in luminal B breast cancer patients. Ctrls, controls; LBBC, luminal B breast cancer; DMCpGs, differentially methylated CpGs; cfDNA, cell-free DNA.