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. 2022 Oct 25;12:1025067. doi: 10.3389/fonc.2022.1025067

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Copyright © 2022 Li, Fu, Fang, Chai, Gao, Chen and Qian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SHK results in ferroptosis induction and exerts antitumor efficacy in vivo. (A) Representative image of RPMI 8226 xenograft tumors after SHK treatment. (B) Tumor volume in each group. (C) Tumor weight in each group. (D) Tumor Fe²⁺ in each group. (E) Tumor ATP level in each group. (F) Tumor MDA level in each group. (G) Tumor GSH level in each group. (H) Tumor GSSG level in each group. (I) IHC staining were used to assess GPX4, 4HNE, GOT1, NCOA4, FTH1 and LC3B levels in tumor tissues. (J) Serum ALT in each group. (K) Body weight in each group. (L) HE stain in liver, kidney and heart of each group. Data are presented as the mean ± SD. ns, not significant; **p < 0.01, ***p < 0.001.