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. 2022 Oct;14(10):4055–4072. doi: 10.21037/jtd-22-1185

Table 2. Pathways enriched in cluster A and cluster B.

Pathways ES NES NOM P value FDR q value
Pathway enriched in cluster B
   KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0.71 2.56 0 0
   KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0.7 2.45 0 0
   KEGG_JAK_STAT_SIGNALING_PATHWAY 0.6 2.32 0 0
   KEGG_ECM_RECEPTOR_INTERACTION 0.79 2.31 0 0
   KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0.64 2.31 0 0
   KEGG_CHEMOKINE_SIGNALING_PATHWAY 0.63 2.23 0 0
   KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.59 2.18 0.002 0.001
   KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0.68 2.16 0.002 0.001
   KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0.86 2.15 0 0.001
   KEGG_MAPK_SIGNALING_PATHWAY 0.44 1.8 0 0.022
Pathway enriched in cluster A
   KEGG_HOMOLOGOUS_RECOMBINATION –0.83 –2.21 0 0.001
   KEGG_OXIDATIVE_PHOSPHORYLATION –0.7 –2.14 0.002 0.004
   KEGG_RNA_POLYMERASE –0.72 –2.11 0 0.004
   KEGG_MISMATCH_REPAIR –0.81 –2.1 0.002 0.003
   KEGG_PYRIMIDINE_METABOLISM –0.58 –2.02 0 0.006
   KEGG_BASAL_TRANSCRIPTION_FACTORS –0.64 –2.02 0.004 0.006
   KEGG_CELL_CYCLE –0.57 –1.86 0.027 0.022
   KEGG_GLUTATHIONE_METABOLISM –0.54 –1.76 0.022 0.039
   KEGG_PROTEASOME –0.67 –1.89 0.014 0.019
   KEGG_AMINOACYL_TRNA_BIOSYNTHESIS –0.64 –1.88 0.016 0.018

ES, Enrichment Score; NES, Normalized Enrichment Score; NOM, Nominal; FDR, false discovery rate.