Table 1.
Clinical characteristics of the 60 ALL patients in the original cohort. Patients were randomly assigned to the training (n=40) or testing cohort (n=20)
| Total | Training | Testing | p-value | |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| Onset age (years) | 0.326 | |||
| <10 | 47 (78.3) | 33 (82.5) | 14 (70.0) | |
| ≥10 | 13 (21.7) | 7 (17.5) | 6 (30.0) | |
| Sex | 1.000 | |||
| Female | 32 (53.3) | 21 (52.5) | 11 (55.0) | |
| Male | 28 (46.7) | 19 (47.5) | 9 (45.0) | |
| Initial WBC (109/L) | 0.189 | |||
| <100 | 48 (80.0) | 34 (85.0) | 14 (70.0) | |
| ≥100 | 12 (20.0) | 6 (15.0) | 6 (30.0) | |
| Risk group | 0.579 | |||
| SR+HR | 39 (65.0) | 27 (67.5) | 12 (60.0) | |
| VHR | 21 (35.0) | 13 (32.5) | 8 (40.0) | |
| Genetic subtypes* | 0.245 | |||
| BCR-ABL1 | 1 (3.5) | 0 (0.0) | 1 (11.1) | |
| ETV6-RUNX1 | 8 (27.6) | 6 (30.0) | 2 (22.2) | |
| Hyperdiploidy | 8 (27.6) | 7 (35.0) | 1 (11.1) | |
| DUX4-rearranged | 1 (3.5) | 0 (0.0) | 1 (11.1) | |
| ZNF384-rearranged | 1 (3.5) | 1 (5.0) | 0 (0.0) | |
| T-ALL | 10 (34.5) | 6 (30.0) | 4 (44.4) |
*
A total of 31 samples had unknown subtype.
WBC, white blood cells; SR, standard risk group; HR, high-risk group; VHR, very high-risk group.