Table 2.
Hazard ratios of head and neck cancer and its subtypes according smoking status
| subsites | Smoking status | N | Event | Incidence Rate | Model 1 | P value | Model 2 | P value |
|---|---|---|---|---|---|---|---|---|
| Head and neck cancer | ||||||||
| Never smoker | 5772362 | 4273 | 0.08969 | 1 (Ref.) | <.0001* | 1 (Ref.) | <.0001* | |
| Ex-smoker | 1325452 | 2239 | 0.2061 | 1.245 (1.174, 1.319) | 1.242 (1.172, 1.317) | |||
| Current smoker | 2500271 | 4220 | 0.20626 | 1.832 (1.739, 1.930) | 1.822 (1.729, 1.92) | |||
| Larynx | ||||||||
| Never smoker | 5772362 | 682 | 0.01431 | 1 (Ref.) | <.0001* | 1 (Ref.) | <.0001* | |
| Ex-smoker | 1325452 | 719 | 0.06616 | 1.669 (1.494, 1.866) | 1.658 (1.483, 1.853) | |||
| Current smoker | 2500271 | 1571 | 0.07676 | 3.294 (2.980, 3.641) | 3.256 (2.945, 3.599) | |||
| Sinonasal cavity | ||||||||
| Never smoker | 5772362 | 280 | 0.00588 | 1 (Ref.) | 0.0755 | 1 (Ref.) | 0.0766 | |
| Ex-smoker | 1325452 | 94 | 0.00865 | 0.981 (0.748, 1.286) | 0.982 (0.749, 1.288) | |||
| Current smoker | 2500271 | 165 | 0.00806 | 1.263 (0.993, 1.606) | 1.264 (0.993, 1.610) | |||
| Hypopharynx | ||||||||
| Never smoker | 5772362 | 271 | 0.00569 | 1 (Ref.) | <.0001* | 1 (Ref.) | <.0001* | |
| Ex-smoker | 1325452 | 193 | 0.01776 | 1.150 (0.946, 1.398) | 1.15 (0.946, 1.398) | |||
| Current smoker | 2500271 | 465 | 0.02272 | 2.252 (1.903, 2.664) | 2.229 (1.883, 2.638) | |||
| Oropharynx | ||||||||
| Never smoker | 5772362 | 685 | 0.01438 | 1 (Ref.) | <.0001* | 1 (Ref.) | <.0001* | |
| Ex-smoker | 1325452 | 418 | 0.03846 | 1.182 (1.033, 1.353) | 1.178 (1.030, 1.348) | |||
| Current smoker | 2500271 | 711 | 0.03473 | 1.564 (1.383, 1.769) | 1.555 (1.374, 1.759) | |||
| Oral cavity | ||||||||
| Never smoker | 5772362 | 1172 | 0.0246 | 1 (Ref.) | <.0001* | 1 (Ref.) | <.0001* | |
| Ex-smoker | 1325452 | 383 | 0.03524 | 1.085 (0.947, 1.243) | 1.081 (0.944, 1.239) | |||
| Current smoker | 2500271 | 670 | 0.03273 | 1.415 (1.254, 1.597) | 1.399 (1.239, 1.580) | |||
| Nasopharynx | ||||||||
| Never smoker | 5772362 | 492 | 0.01033 | 1 (Ref.) | 0.0276* | 1 (Ref.) | 0.0269* | |
| Ex-smoker | 1325452 | 237 | 0.0218 | 1.175 (0.984, 1.404) | 1.177 (0.985, 1.405) | |||
| Current smoker | 2500271 | 372 | 0.01817 | 1.245 (1.058, 1.466) | 1.247 (1.059, 1.469) | |||
| Salivary gland | ||||||||
| Never smoker | 5772362 | 733 | 0.01538 | 1 (Ref.) | 0.0537 | 1 (Ref.) | 0.0485 | |
| Ex-smoker | 1325452 | 220 | 0.02024 | 1.213 (1.011, 1.456) | 1.214 (1.011, 1.457) | |||
| Current smoker | 2500271 | 320 | 0.01563 | 1.201 (1.015, 1.421) | 1.208 (1.020, 1.431) | |||
Incidence rate per 1,000 person-years. Model 1: Age, sex, income, BMI, alcohol consumption, regular exercise, diabetes, and hypertension. Model 2: Age, sex, income, BMI, waist circumference, alcohol consumption, regular exercise, diabetes, hypertension, hyperlipidemia, chronic kidney disease, HDL level, LDL level, and triglyceride level.
*
Significant at p<0.05.