Figure 4.
Effect of IVM on the growth of HCT-8 xenograft tumor in vivo. The NOD/SCID mice were injected subcutaneously with 1 × 107 HCT-8 cells. When the tumor reached to about 100 mm3, the mice were treated with IVM (2 or 3 mg/kg) by intraperitoneal injection daily for 18 days. (A) Tumor volumes from day 0 to day 18. (B and C) The weights (B) and images (C) of the tumors at the last day of IVM treatment. Mice treated with vehicle served as control. Data in (A and B) were presented as the mean ± SD (n = 3). *P < 0.05, compared with the vehicle controls.