Figure 2. iPSCs offer a unique patient‐specific model to study the effect of the environment on the human body.

New or unrecognized environmental toxins such as particulate matter 2.5 (PM_2.5) from forest fires and industrial pollution, marijuana, e‐cigarette, radiation, or toxic waste exposure might cause adverse effects on the human body. iPSC disease modeling is an opportunity to study the effects of environmental toxins before they result in end‐organ damage or organ failure. iPSCs can be differentiated into organ‐specific cells and assembled into fabricated tissues such as engineered heart tissue or differentiated into organoids comprised of organ‐specific tissue. Using single‐cell RNA sequencing (scRNA‐seq), mass spectrometry, and other ‐omic analysis, iPSC disease modeling could be leveraged to discover harmful effects of environmental factors before epidemiology studies are available and prevent significant morbidity and mortality. The discovery of druggable targets and pathways might lead to the development of new biomarkers and therapies for disease. [Colour figure can be viewed at wileyonlinelibrary.com]