Figure 2.

Exos alleviated CLP-induced organ damage in septic mice. (A) Survival rate of mice after cecal ligation and puncture (CLP) procedures and Exo treatment at different time points; (B-D) Pathologic changes in murine lung (B), kidney (C), and liver (D) tissues examined by HE staining. In the survival analysis in (A), n = 10 in each group, while in the subsequent experiments, n = 6 in each group. The survival rate of mice was analyzed by Log-rank test (A). Differences in (B-D) were analyzed by one-way ANOVA followed by Tukey’s multiple comparison. *P < 0.05 vs. the sham group; #P < 0.05 vs. the CLP group.