Incidence of surgical-site infection (SSI) among different cohorts of surgical patients. The symbols represent organisms causing infection: methicillin-sensitive Staphylococcus aureus (MSSA); organisms other than S. aureus or organisms that could not be cultured (other or not isolated). Between the January 1, 2012, and July 8, 2016, 1,268 patients underwent hip or knee prosthetic joint surgery. Of those, 754 were screened and 256 were decolonized. Of 453 patients screened but not decolonized, 7 primary surgical patients went on to develop an SSI (1.5%). The revision surgery group had the highest incidence for infection overall, with 5 patients (3.9%) who developed infection among 128 patients. The decolonized group had the lowest incidence of infection; no infection with S. aureus was observed in the decolonized group. No difference was observed in the frequency of infection due to other species between the decolonized and non-decolonized groups (0.8%; cf, 1.0%).