Table 1:
Demographic and clinical characteristics of patients with virologically cured HCV and cirrhosis. Table also shows evolution of these characteristics over time.
| Baseline (N=29,398) | 12-month landmark (N=26,648) | 24-month landmark (N=21,600) | |
|---|---|---|---|
| Demographics | |||
| Age in years, mean (SD) | 62.78 (5.95) | 63.67 (5.91) | 64.48 (5.8) |
| Sex (n, percent) | |||
| Male | 28567 (97.17) | 25884 (97.13) | 20952 (97.0) |
| Female | 831 (2.83) | 764 (2.87) | 648 (3.0) |
| Race/ethnicity | |||
| White not Hispanic | 15107 (51.39) | 13618 (51.1) | 11084 (51.31) |
| African American | 10803 (36.75) | 9873 (37.05) | 7966 (36.88) |
| White Hispanic | 1383 (4.7) | 1264 (4.74) | 1040 (4.81) |
| Other | 727 (2.47) | 660 (2.48) | 534 (2.47) |
| Missing | 1378 (4.69) | 1233 (4.63) | 976 (4.52) |
| Clinical characteristics | |||
| HCV genotype | |||
| 1a | 16198 (55.1) | 14738 (55.31) | 11948 (55.31) |
| 1a/1b | 1043 (3.55) | 950 (3.56) | 773 (3.58) |
| 1b | 6393 (21.75) | 5800 (21.77) | 4815 (22.29) |
| 1-unknown subtype | 841 (2.86) | 781 (2.93) | 678 (3.14) |
| 2 | 2356 (8.01) | 2116 (7.94) | 1634 (7.56) |
| 3 | 1806 (6.14) | 1577 (5.92) | 1191 (5.51) |
| 4, 5, or 6 | 255 (0.87) | 235 (0.88) | 191 (0.88) |
| Missing | 506 (1.72) | 451 (1.69) | 370 (1.71) |
| Prior HCV treatment | |||
| No | 18241 (62.05) | 16447 (61.72) | 13060 (60.46) |
| Yes | 11157 (37.95) | 10201 (38.28) | 8540 (39.54) |
| FIB-4 | |||
| <1.45 | 5859 (19.93) | 6160 (23.12) | 5430 (25.14) |
| 1.45–3.25 | 12756 (43.39) | 13300 (49.91) | 10569 (48.93) |
| >3.25 | 10667 (36.28) | 6571 (24.66) | 4568 (21.15) |
| Missing | 116 (0.39) | 617(2.31) | 1033 (4.78) |
| Cirrhosis duration, months, | 76.92 (57.64) | 88.45 (57.17) | 100.25 (56.17) |
| Cirrhosis duration, categorical | |||
| < 1 year | 4874 (16.58) | -- | -- |
| 1–<2 years | 2424 (8.25) | 4380 (16.44) | -- |
| 2–<5 years | 5873 (19.98) | 5800 (21.77) | 6669 (30.88) |
| ≥ 5 years | 16227 (55.2) | 16468 (61.8) | 14931 (69.13) |
| Varices | |||
| No | 25800 (87.76) | 24644 (92.48) | 19522 (90.38) |
| Yes | 3598 (12.24) | 2004 (7.52) | 2078 (9.62) |
| Ascites | |||
| No | 27187 (92.48) | 25735 (96.57) | 20747 (96.05) |
| Yes | 2211 (7.52) | 913 (3.43) | 853 (3.95) |
| Diabetes | |||
| No | 16618 (56.53) | 14667 (55.04) | 11575 (53.59) |
| Yes | 12780 (43.47) | 11981 (44.96) | 10025 (46.41) |
| Hypertension | |||
| No | 3943 (13.41) | 3102 (11.64) | 2226 (10.31) |
| Yes | 25455 (86.59) | 23546 (88.36) | 19374 (89.69) |
| Body mass index | |||
| <18.5 | 365 (1.24) | 346 (1.3) | 283 (1.31) |
| 18.5–<25 | 7683 (26.13) | 6513 (24.44) | 4967 (23) |
| 25–<30 | 11144 (37.91) | 9639 (36.17) | 7528 (34.85) |
| ≥30 | 10103 (34.37) | 9501 (35.65) | 7742 (35.84) |
| Missing | 103 (0.35) | 649 (2.44) | 1080 (5.0) |
| Dyslipidemia | |||
| No | 14089 (47.93) | 12808 (48.06) | 9598 (44.44) |
| Yes | 15309 (52.07) | 13840 (51.94) | 12002 (55.56) |
| Chronic kidney disease | |||
| No | 25357 (86.25) | 22725 (85.28) | 18410 (85.23) |
| Yes | 4041 (13.75) | 3923 (14.72) | 3190 (14.77) |
| COPD | |||
| No | 19541 (66.47) | 17477 (65.58) | 14085 (65.21) |
| Yes | 9857 (33.53) | 9171 (34.42) | 7515 (34.79) |
| Heart failure | |||
| No | 26134 (88.9) | 23569 (88.45) | 19127 (88.55) |
| Yes | 3264 (11.1) | 3079 (11.55) | 2473 (11.45) |
| Behavioral factors | |||
| Active alcohol use disorder | |||
| No | 22050 (75.01) | 19339 (72.57) | 15511 (71.81) |
| Yes | 3984 (13.55) | 2675 (10.04) | 2264 (10.48) |
| Missing | 3364 (11.44) | 4634 (17.39) | 3825 (17.71) |
| Smoking | |||
| Current | 13484 (45.87) | 11269 (42.29) | 8601 (39.82) |
| Former | 6721 (22.86) | 6012 (22.56) | 5174 (23.95) |
| Non-Smoker | 3614 (12.29) | 3253 (12.21) | 2898 (13.42) |
| Unknown/Missing | 5579 (18.98) | 6114 (22.94) | 4927 (22.81) |
| Laboratory data (mean, SD) | |||
| Albumin (g/dL) | 3.78 (0.47) | 3.8 (0.46) | 3.78 (0.45) |
| Bilirubin (mg/dL) | 0.93 (0.65) | 0.92 (0.62) | 0.92 (0.61) |
| Sodium (mmol/L) | 138.4 (3.03) | 138.4 (3.01) | 138.4 (2.94) |
| Creatinine (mg/dL) | 1.16 (1.1) | 1.21 (1.18) | 1.2 (1.11) |
| Hemoglobin (g/dL) | 13.4 (1.85) | 13.4 (1.83) | 13.4 (1.8) |
| INR* | 1.13 (0.26) | 1.26 (0.79) | 1.25 (0.73) |
*
There were 10.5% missing INR at baseline, 38.4% missing at 12-month landmark time, and 54.1% missing at 24-month landmark time.