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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Nat Neurosci. 2022 Oct 24;25(11):1407–1419. doi: 10.1038/s41593-022-01177-4

Figure 1. Chemical phylogeny of psychedelics.

Figure 1.

(a) The basic psychedelic pharmacophore is highlighted in blue. Tryptamine and phenethylamine pharmacophores are highlighted in gray and yellow, respectively. Ergolines (LSD, 1P-LSD) can be viewed chemically as a specialized case of tryptamines. Branches indicate structurally related compounds. Natural products are indicated with asterisks. (b) LSD has the phenethylamine substructure (yellow) embedded and can thus contains the key elements of both psychedelic structural families. (c) Structures of non-hallucinogenic psychedelic analogs with therapeutic potential, which may contain the tryptamine-like (gray) or phenethylamine-like (yellow) pharmacophore.