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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Nat Neurosci. 2022 Oct 24;25(11):1407–1419. doi: 10.1038/s41593-022-01177-4

Figure 2. The 5-HT2A receptors and molecular signaling pathways.

Figure 2.

(a) Intracellular signal transduction pathways. Downstream of the 5-HT2A receptor, activation of heterotrimeric G proteins and subsequent intracellular signaling (Ca2+ release and diacylglycerol (DAG) production) synergistically activate additional downstream effects, which ultimately lead to altered neuronal firing. (b) left: Structure of the 5-HT2A receptor; right: A model of the 5-HT2A receptor signaling complex in the membrane.