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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Lancet HIV. 2022 Oct;9(10):e700–e708. doi: 10.1016/S2352-3018(22)00219-3

Table 3.

Relative risks from multivariable Poisson regression of lung cancer and histologic subtypes among people living with HIV in the United States in 2001–2016.

Factor Lung SCC Adeno Small Large
Calendar year, per year 0·94 (0·94, 0·95) 0·96 (0·94, 0·97) 0·97 (0·96, 0·98) 0·94 (0·91, 0·97) 0·86 (0·81, 0·90)
Age group
20–39 0·05 (0·04, 0·07) 0·02 (0·01, 0·03) 0·04 (0·03, 0·06) 0·04 (0·02, 0·08) 0·05 (0·01, 0·15)
40–49 0·35 (0·32, 0·38) 0·27 (0·22, 0·33) 0·36 (0·31, 0·41) 0·24 (0·17, 0·33) 0·31 (0·18, 0·53)
50–59 Ref Ref Ref Ref Ref
60–69 2·09 (1·92, 2·27) 2·41 (2·05, 2·84) 1·88 (1·64, 2·16) 2·53 (1·93, 3·29) 2·03 (1·16, 3·44)
70+ 3·04 (2·64, 3·49) 4·39 (3·44, 5·53) 2·35 (1·84, 2·97) 3·10 (1·92, 4·77) 2·00 (0·6, 5·00)
HIV risk group
Male other / unknown Ref Ref Ref Ref Ref
Female other / unknown 0·89 (0·80, 0·99) 0·68 (0·55, 0·84) 1·08 (0·92, 1·27) 1·33 (0·94, 1·89) 1·23 (0·68, 2·23)
Male PWID 1·26 (1·15, 1·39) 1·17 (0·97, 1·41) 1·43 (1·22, 1·67) 1·41 (0·99, 2·01) 1·01 (0·52, 1·90)
Female PWID 1·62 (1·44, 1·83) 1·10 (0·84, 1·43) 1·92 (1·59, 2·31) 2·57 (1·73, 3·80) 1·54 (0·70, 3·14)
MSM 0·63 (0·57, 0·70) 0·48 (0·39, 0·59) 0·79 (0·67, 0·93) 0·97 (0·69, 1·35) 0·52 (0·26, 0·99)
Race and ethnicity
Hispanic 0·46 (0·41, 0·52) 0·43 (0·34, 0·54) 0·55 (0·46, 0·66) 0·43 (0·30, 0·62) 0·22 (0·08, 0·51)
Non-Hispanic Black 1·07 (0·99, 1·17) 0·90 (0·76, 1·06) 1·23 (1·07, 1·40) 0·83 (0·64, 1·09) 1·02 (0·62, 1·73)
Non-Hispanic White Ref Ref Ref Ref Ref

SCC (squamous cell carcinoma): ICD-O3 code 8051–2,8070–6, 8078, 8083–4, 8090, 8094, 8120, 8123

Adeno (adenocarcinoma): ICD-O3 code 8015,8050, 8140–1, 8143–5, 8147, 8190, 8201, 8211, 8250–5,8260, 8290, 8310, 8320, 8323, 8333, 8401, 8440, 8470–1, 8480–1, 8490, 8503, 8507, 8550, 8570–2, 8574, 8576

Small (small cell carcinoma): ICD-O3 code 8002, 8041–5

Large (large cell carcinoma): ICD-O3 code 8012–4, 8021, 8034, 8082

Other histologies included in lung cancers: carcinoma not otherwise specified (NOS) (8010); bronchioloalveolar carcinoma (8253), adenosquamous carcinoma (8560); giant cell and spindle cell carcinoma (8031); carcinoid tumor NOS (8240); sarcoma NOS (8800/3); solid carcinoma NOS (8230); spindle cell sarcoma (8801)