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. 2022 Oct 3;149(19):dev200986. doi: 10.1242/dev.200986

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Presentation of overall pathway map of MAPK/ERK metabolic effects identified by integrating metabolomics and RNA-seq data. Quantitated metabolites and enzymes are represented in pink (downregulated) and green (upregulated). Dotted boxes represent metabolic pathways including metabolites and genes. 5-methylthioadenosine, 5-MTA; alpha-ketoglutarate, a-KG; acetyl-coenzyme A acyltransferase 1A, ACAA1A; acetyl-CoA acyltransferase 2, ACAA2; acyl-CoA dehydrogenase short-chain, ACADS; acyl-CoA dehydrogenase very long chain, ACADVL; aconitate hydratase 1, ACO1; peroxisomal acyl-coenzyme A oxidase 1, ACOX1; adenylosuccinate lyase, ADSL; adenosine monophosphate, AMP; asparagine synthetase, ASNS; creatine kinase B-type, CKB; citramalyl-CoA lyase, CLYBL; carnitine palmitoyltransferase 1, CPT1; carnitine palmitoyltransferase 2, CPT2; enoyl coenzyme A hydratase 1, ECH1; short-chain enoyl-CoA hydratase, ECHS1; β-enolase, ENO3; fatty acid synthase, FASN; glyceraldehyde-3-phosphate dehydrogenase, GAPDH; glutamate-cysteine ligase catalytic subunit, GCLC; glutamate-cysteine ligase regulatory subunit, GCLM; glutaminase, GLS; glucose transporter 1, GLUT1; aspartate aminotransferase, GOT2; glutathione peroxidase, GPx; glutathione, GSH; glutathione synthetase, GSS; 3-hydroxyacyl-CoA dehydrogenase, HADH; intermediate of purine metabolism, IMP; ornithine decarboxylase, ODC1; pyrroline 5-carboxylate, P5C; probable proline-tRNA ligase, PARS2; phosphoenolpyruvate carboxykinase 1, PCK2; phosphoglycerate mutase 1, PGAM1; phosphoglycerate kinase 1, PGK1; D-3-phosphoglycerate dehydrogenase, PHGDH; pyruvate kinase, PKM; pyrroline-5-carboxylate reductase 1, PYCR1; pyrroline-5-carboxylate reductase, PYCRL; ribulose-phosphate 3-epimerase, RPE; S-adenosylhomocysteine, S-AMP; S-adenosylhomocystein, SAH; S-adenosyl methionine, SAM; sarcosine dehydrogenase, SARDH; serine hydroxymethyltransferase 2, SHMT2; solute carriers, SLCs; transketolase, TKT.