Table 1.

Clinical characteristics in controls and patients with Cushing’s syndrome (CS) and mild autonomous cortisol secretion (MACS). Categorical variables are expressed as frequency and percentages. Continuous variables are expressed as mean ± s.d.

	All subjects	Controls	CS	P*	MACS	P*
n	780	570	43		32
Age (years)	49.9 ± 16	49.1 ± 16	46.2 ± 12	0.243	65 ± 8	<0.001
Females	424 (54%)	294 (52%)	37 (86%)	<0.001	24 (75%)	0.065
Diabetes	71 (9%)	38 (7%)	14 (33%)	<0.001	3 (9%)	1.000
Obesity	124 (16%)	78 (14%)	17 (39.5%)	<0.001	8 (25%)	0.514
Menopause/hypogonadism	382 (49%)	266 (47%)	20 (46.5%)	0.914	26 (81%)	0.002
Smokers	150 (19%)	99 (17%)	10 (23%)	0.443	8 (25%)	0.389

^*P values for comparisons with controls.