Table 3.

Prevalence and treatment of infectious diseases, hospitalization, vaccination, absence from work due to infectious disease, and ICARO score in controls and in patients with Cushing’s syndrome (CS) and mild autonomous cortisol secretion (MACS). Categorical variables are expressed as percentages and frequencies. Continuous variable is expressed as median (25th–75th percentile).

	Controls (n = 570)	CS (n = 43)	P*	MACS (n = 32)	P*	P§
Upper respiratory tract infections	75% (429/570)	81% (35/43)	0.738	87.5% (28/32)	0.150	0.693
Antimicrobials	36% (154/429)	40% (14/35)	0.742	46% (13/28)	0.925	0.819
Lower respiratory tract infections	11% (64/570)	23% (10/43)	0.086	25% (8/32)	0.150	0.861
Antimicrobials	73% (47/64)	80% (8/10)	0.892	87.5% (7/8)	0.985	0.769
Gastrointestinal tract infections	32.5% (185/570)	49% (21/43)	0.112	31% (10/32)	1.000	0.126
Antimicrobials	18% (33/185)	9.5% (2/21)	0.732	20% (2/10)	1.000	0.810
Skin infections 1	25% (142/570)	23% (10/43)	1.000	25% (8/32)	1.000	0.861
Antimicrobials	39% (55/142)	90% (9/10)	0.019	50% (4/8)	1.000	0.065
Skin infections 2	15% (88/570)	23% (10/43)	0.459	12.5% (4/32)	1.000	0.377
Antimicrobials	27% (24/88)	20% (2/10)	0.054	25% (1/4)	1.000	0.837
Mycosis	11% (63/570)	42% (18/43)	0.018	16% (5/32)	0.899	0.029
Antimicrobials	81% (51/63)	83% (15/18)	1.000	40% (2/5)	0.360	0.169
Sexually transmitted infections	2% (9/570)	2% (1/43)	0.951	3% (1/32)	1.000	1.000
Antimicrobials	56% (5/9)	100% (1/1)	0.752	0% (0/1)	1.000	1.000
Urinary tract infections	15% (86/570)	53.5% (23/43)	0.015	44% (14/32)	0.013	0.548
Antimicrobials	76% (65/86)	74% (17/23)	1.000	36% (5/14)	0.062	0.051
Flu	42% (240/570)	67% (29/43)	0.021	59% (19/32)	0.082	0.634
Hospitalization due to infectious disease	1% (5/570)	2% (1/43)	0.736	3% (1/32)	0.977	0.832
Vaccination	20% (112/570)	21% (9/43)	1.000	34% (11/32)	0.260	0.299
Absence from work due to infectious disease	10% (56/570)	12% (5/43)	0.948	3% (1/32)	0.757	0.362
ICARO score	9.5 (6–13)	16 (9–20.5)	0.014	11.25 (7.5–16.5)	0.034	0.049

After correction for multiple testing, P < 0.05 was considered statistically significant (bold).

^*P values for comparisons with controls; ^§P values for comparisons between CS and MACS.