Table 1.
Clinical characteristics of study participants
| Characteristic | No. patients | Percentage | |
|---|---|---|---|
| Total | 259 | 100 | |
| Sex | |||
| Male | 194 | 74.9 | |
| Female | 65 | 25.1 | |
| Median age (range); years | 49 (19–74) | ||
| T category | |||
| T 1–2 | 34 | 13.1 | |
| T 3–4 | 225 | 86.9 | |
| N category | |||
| N 0–1 | 89 | 34.4 | |
| N 2–3 | 170 | 65.6 | |
| Stage | |||
| III | 129 | 49.8 | |
| IVA | 130 | 50.2 | |
| Plasma EBV-DNA (copies/mL) | |||
| ≤ 500 | 173 | 66.8 | |
| > 500 | 86 | 33.2 | |
| 95% of target volume received dose greater than (D95, Gy) | |||
| Average dose of nasopharynx (PTVnx + rn) (range) | 70.2 (66.1–74.3) | ||
| Average dose of neck node (PTVnd) (range) | 69.4 (60.7–75.9) | ||
| Sites of residual | |||
| Primary focus | 121 | 46.7 | |
| Retropharyngeal lymph nodes | 54 | 20.8 | |
| Cervical lymph nodes | 152 | 58.7 | |
| Median time to boost after RT (range); days | 36 (1–74) | ||
| Average boost dose for primary focus (range); Gy | 8.1 (4–12.5) | ||
| Average boost dose for retropharyngeal lymph nodes (range); Gy | 8.3 (5–12.5) | ||
| Average boost dose for cervical lymph nodes (range); Gy | 8.6 (4–18) | ||
EBV-DNA Epstein-Barr virus-deoxyribonucleic acid, PTVnx + rn planning gross target volume of the nasopharyngeal and retropharyngeal lymph node, PTVnd planning gross target volume of the cervical lymph nodes, RT radiotherapy