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. 2022 Nov 7;23:960. doi: 10.1186/s12891-022-05937-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effect of DF-HA on the pressure withdrawal threshold applied to one posterior ipsilateral limb Changes in hyperalgesia are measured using a von Frey filament and expressed in grams (g) as a 50% paw withdrawal threshold. Behavioral tests are performed before MIA administration (BL). Further, 2 mg of MIA is administered, and the von Frey test is performed weekly for 8 weeks. DF-HA (DF-HA group) or vehicle (vehicle group) is administered at week 4 and FG is administered at week 7 after the test. Lower threshold values indicate enhanced hyperalgesia. Data are expressed as the mean ± standard error of four animals per group