Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 8;8:79. doi: 10.1186/s40942-022-00431-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Complement Deposition on POS in Mouse Models of GA and in GA Patient Tissue: Panel A: Image of mouse retinal Sect. 5 h after RPE damage caused by intravenous injection of NaIO_3. Immunofluorescence shows C1q deposition on POS, which occurs in conjunction with C3 prior to decrease in retinal function by day 7; Panels B and C: Images of retinal sections from patients with GA. Immunofluorescence shows C4 and C3 deposition on photoreceptor cell outer segments (POS) in a healthy region of retina just outside the edge of an expanding lesion, consistent with complement activation preceding loss of photoreceptor neurons. C4 deposition directly implicates the classical and/or lectin pathways since it occurs upstream of C3 and the alternative or amplification pathways [6]