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. 2022 Nov 8;8:79. doi: 10.1186/s40942-022-00431-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ApoE-rich Deposits That Form Below Cultured RPE Cells Activate the Classical Complement Pathway:Primary human RPE cells grown on porous supports produce globular extracellular deposits. Cultures were exposed to normal or complement-depleted human serum and then processed for immunohistochemistry with various antibody markers. A. Anti-ApoE with no serum exposure; B. Anti-C1q after exposure to normal human serum; C. Anti-C5b-9 after exposure to normal human serum; D. Anti-C5b-9 after expsoure to C1q-depleted human serum. Depletion of factor B had no impact on C5b-9 staining, implicating C1q-dependent/classical cascade activation [96]