Table 1.
Characteristics in subjects of European ancestry.
| Characteristic | ADRC | ROSMAP (n = 1266) | |
|---|---|---|---|
| ADSP WGS (n = 1028) | ADGC (n = 2200) | ||
| Age at death, mean ± SD | 82.5 ± 10.5 | 82.2 ± 10.6 | 89.7 ± 6.5 |
| Years in education, mean ± SD | 16.5 ± 9.1 | 16.3 ± 8.2 | 16.3 ± 3.7 |
| Sex, n (%) | |||
| Male | 529 (51.5) | 1173 (53.3) | 412 (32.5) |
| Female | 499 (48.5) | 1027 (46.7) | 854 (67.5) |
| APOE, n (%) | |||
| −/− | 526 (51.2) | 1155 (52.5) | 952 (75.2) |
| −/ε4 | 438 (42.6) | 798 (36.3) | 293 (23.1) |
| ε4/ε4 | 64 (6.2) | 247 (11.2) | 21 (1.7) |
| Braak NFT stage, n (%) | |||
| 0 – IV | 374 (36.5) | 909 (41.5) | 916 (72.4) |
| V/VI | 652 (63.5) | 1282 (58.5) | 350 (27.6) |
| Neocortical neuritic plaques, n (%) | |||
| No – moderate | 466 (45.3) | 1072 (48.8) | 840 (66.4) |
| Frequent | 562 (54.7) | 1123 (51.2) | 426 (33.6) |
| TDP-43 in any brain regions, n (%) | |||
| No | 273 (75.0) | 520 (65.2) | 554 (47.1) |
| Yesa | 91 (25.0) | 277 (34.8) | 622 (52.9) |
| Lewy bodies in any brain regions, n | (%) | ||
| No | 661 (64.6) | 1388 (63.5) | 927 (75.7) |
| Yesb | 362 (35.4) | 797 (36.5) | 298 (24.3) |
| Hippocampal sclerosis, n (%) | |||
| No | 418 (87.4) | 962 (86.7) | 1133 (91.1) |
| Yesc | 60 (12.6) | 147 (13.3) | 111 (8.9) |
Abbreviations: ADGC = Alzheimer’s Disease Genetics Consortium; ADRC = Alzheimer’s Disease Research Center; ADSP = Alzheimer’s Disease Sequencing Project; NFT = neurofibrillary tangle; ROSMAP = Religious Orders Study (ROS) and Memory and Aging Project (MAP); SD = standard deviation; TDP-43 = TAR DNA binding protein 43 kDa; WGS = whole genome sequencing.
a
Observed in any regions including amygdala, hippocampus, entorhinal/inferior temporal cortex, and neocortex.
b
Observed in any brain regions including brainstem-predominant, limbic, neocortical, amygdala predominant, and olfactory bulb.
c
Observed in either unilateral or bilateral.