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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Lancet Oncol. 2022 Oct 13;23(11):1409–1418. doi: 10.1016/S1470-2045(22)00599-X

Figure 1: Chronic CED of TPT achieves large and stable volumes of distribution.

Figure 1:

A: Each patient was infused over the course of 48 hours followed by a 5–7 day washout period before the next infusion. All five patients showed large changes in volume of distribution. B: The estimated volume of distribution of the infused contrast was plotted as a function of time and fit to a gamma function for each patient. The solid black line represents the mean time course across subjects, which peaked at 43.1 hours with a mean volume of 20.4 mL.